SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. [5] [6] SH2B3 is ubiquitously expressed in many tissues and cell types. [7] LNK functions as a regulator in signaling pathways relating to hematopoiesis, inflammation, and cell migration. [8]

We found that loss of LNK leads to enhanced vascular and renal inflammation at baseline and that this is further exacerbated by Ang II infusion. BM transplantation studies showed that the predominant effect of LNK in BP regulation is through the hematopoietic compartment, further emphasizing the critical role of the immune system in hypertension.

告描述了淋巴细胞衔接蛋白（lnk；也被 称为sh2b3）在血管紧张素ii（ang ii）诱 导的高血压、相关的血管和肾脏功能不全 中的角色。lnk是细胞因子信号通路和细 胞增殖的负向调节因子，但在此项最新研 究之前，对于此蛋白影响血压（bp）的机 制尚不清楚。

LNK/SH2B3 is a key driver gene for human hypertension, and alteration of LNK in animal models has a profound effect on inflammation and hypertension. Thus, LNK is a potential therapeutic target for this disease and its devastating consequences.

2025年2月27日 · It has been identified that many genetic variants are responsible for blood pressure, such as mutations in lymphocyte ligand protein (LNK) position 262 (R262W), which are related with many cardiovascular and autoimmune diseases, such as hypercholesterolemia, type-I diabetes, and hypertension [4].

2001年6月5日 · Rudd discusses the role of Lnk in B cells and hypothesizes a mechanism whereby Lnk, and its closely related protein family members, the adaptor molecules containing pleckstrin homology (PH) and Src-homology 2 (SH2) domains (APS), and Src-homology 2-B protein (SH2-B), may mediate signal promotion or attenuation.

SH2B3, also known as LNK, is an intracellular adaptor protein and negative regulator of signaling downstream of a variety of cytokine receptors and receptor tyrosine kinases. 15 The major known role of SH2B3 is in negative regulation of inflammatory cytokine and hematopoietic growth factor signaling. 14, 15 Consistent with this, in addition to ...

2024年2月19日 · There are so many terms found on bank and credit card statements and utility bills. This guide gives a full rundown, including breakdowns of popular gobbledygook, and reveals how to query terms on itemised bills and bank statements if they remain unclear. Why should you check your statements?

2022年9月28日 · Taken together, these results suggest that the Trp encoding allele of rs3184504 is causal for BP elevation and renal dysfunction, in part through loss of SH2B3-mediated repression of T cell IL-12 signaling leading to enhanced IFNg production.

2017年5月9日 · In this review we summarize the current knowledge of LNK function in normal hematopoiesis, the different SH2B3 mutations reported to date and discuss how these genetic variations may influence...