LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977. They are adherent epithelial cells growing in aggregates and as single cells.

LNCaP clone FGC is a cell line exhibiting epithelial morphology that was isolated in 1977 by J.S. Horoszewicz, et al., from a needle aspiration biopsy of the left supraclavicular lymph node of a 50-year-old, White, male (blood type B+) with confirmed diagnosis of metastatic prostate carcinoma.

2022年5月3日 · Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression.

The LNCaP cell line was established from a metastatic lesion of human prostatic adenocarcinoma. The LNCaP cells grow readily in vitro (up to 8 x 10(5) cells/sq cm; doubling time, 60 hr), form clones in semisolid media, are highly resistant to human fibroblast interferon, and show an aneuploid (modal …

LNCaP cells are epithelial cells with weakly-adherent qualities. They grow well in vitro, albeit slowly, and can be grown in aggregates or as individual cells. The cells attach lightly to the surface of the flask, they acidify the complete medium in which they are …

Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.

LNCaP (Lymph Node Carcinoma of the Prostate) is a commonly used human cell line in the cancer research field. These cells are extensively applied to study the biology of prostate cancer and to evaluate potential treatments.

2022年5月3日 · Among the relatively few established human prostate cancer cell lines, LNCaP cells are unique in their ability to model key stages of prostate cancer progression. Analyses of LNCaP cells and their derivatives have been invaluable for elucidating important translational aspects of prostate tumorigene …

The LNCaP cell line, its descending sublines and clonal derivatives provide a suitable in vitro model for studying different aspects of androgen-responsiveness of human prostate cancer.

LNCaP Cells: Transfection and Cell Culture Protocols. The LNCaP cell line (Lymph Node Carcinoma of the Prostate) is derived from human prostate adenocarcinoma cells from a lymph node metastasis. LNCaP cells are androgen-sensitive adherent epithelial cells that grow in aggregates as well as in single cells.