6 天之前 · LMNB1 (Lamin B1) is a Protein Coding gene. Diseases associated with LMNB1 include Microcephaly 26, Primary, Autosomal Dominant and Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant, Typical. Among its related pathways are Apoptosis and survival FAS signaling cascades and Defective Intrinsic Pathway for Apoptosis.

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. [5][6][7] The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution.

2024年6月1日 · Recent findings show that LMNB1 protein dysfunction interferes with the cellular senescence process, which is highly associated with tumor progression. LMNB1 expression levels vary in different...

This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

核纤层蛋白根据其生化特性分为A型和B型。 A型包括lamin A、lamin AΔ10、lamin C和lamin C2，其均由 LMNA 基因所编码，为转录后不同剪接修饰的产物。 B型包括lamin B1、lamin B2和lamin B3，分别由 LMNB1 和 LMNB2 基因编码，lamin B3为lamin B2的短转录本 [3 - 4]。

2025年2月9日 · Title: Lamin B1: a novel biomarker in adult and pediatric adrenocortical carcinoma. Decreased lamin A and B1 expression results in nuclear enlargement in serous ovarian carcinoma, whereas lamin A-expressing tumor cells metastasize to lymph nodes.

2024年3月22日 · Our findings suggest that, while B-type lamin degradation does not significantly change genome topology, it has major implications for three-dimensional chromatin conformation at the single-cell level both at the lamina-associated periphery and the non-LAD-associated nuclear interior with concomitant genome-wide transcriptional changes.

2020年10月9日 · We identify dominant pathogenic variants in LMNB1 and LMNB2 as a genetic cause of primary microcephaly, implicating a major structural component of the nuclear envelope in its etiology and defining...

2024年2月19日 · This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

All B-type lamins are synthesized as precursors and undergo sequential post-translational modifications to generate the mature protein. B-type lamins are involved in a wide range of nuclear functions, including DNA replication and repair, regulation of …