Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis ...
2013年11月13日 · LGI1 antibodies associated with LE specifically inhibited the ligand-receptor interaction between LGI1 and ADAM22/23 by targeting the EPTP repeat domain of LGI1 and …
lgi1 是一种相对分子质量为60 kd的神经元 分泌蛋白，因其最初从胶质瘤细胞中分离出来而 得名[11]。大脑中的lgi1 主要分布于海马和颞叶皮 层，表达在神经元轴突和谷氨酸能突触的起始 …
A patient-derived mutation of epilepsy-linked LGI1 increases …
2023年2月20日 · We identified a novel secretion-defective LGI1 mutation from a Chinese ADLTE family, LGI1-W183R. We specifically expressed mutant LGI1W183R in excitatory neurons …
Cell Biosci︱河南大学魏建设与浙大医学院陈炜/沈颖团队：患者来源的癫痫相关LGI1 …
常染色体显性侧颞叶癫痫 （autosomal dominant lateral temporal epilepsy， ADLTE）是一种由 富含 亮氨酸 的胶质瘤失活1 （leucine-rich glioma inactivated 1， LGI1）基因突变引起的遗传综 …
The LGI1 protein: molecular structure, physiological functions and ...
2021年12月30日 · Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system development and physiology. …
Role of LGI1 protein in synaptic transmission: From physiology to ...
2021年12月1日 · In this review, we will focus on LGI1 binding partners, “A Disintegrin And Metalloprotease (ADAM) 22 and 23”, the complex they form at the synapse, and will discuss …
The LGI1 protein: molecular structure, physiological functions and ...
2021年12月30日 · Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system development and physiology. …
Clinical features of limbic encephalitis with LGI1 antibody
LGI1 LE is an autoimmune encephalitis whose clinical manifestations are memory deterioration, FBDS, epileptic seizure, mental disorders, and hyponatremia. Brain MRI shows that this …
Structural basis of epilepsy-related ligand–receptor complex LGI1 ...
2018年4月18日 · Epilepsy-related ligand–receptor complex, LGI1–ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations...
LGI1-antibody encephalitis - Autoimmune Encephalitis Alliance
LGI1 (Leucine-rich glioma-inactivated 1) antibody encephalitis is an autoantibody mediated form of limbic encephalitis. It is the most common antibody-mediated encephalopathy in those over …