Leucine-rich, glioma inactivated 1, also known as LGI1, is a protein which in humans is encoded by the LGI1 gene. [5] . It may be a metastasis suppressor. The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines.

LGI1 (Leucine-rich glioma-inactivated 1) antibody encephalitis is an autoantibody mediated form of limbic encephalitis. It is the most common antibody-mediated encephalopathy in those over 50 years of age.

2021年12月30日 · Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system development and physiology. Mutations of LGI1 have been linked to autosomal dominant …

Leucine-rich glioma-inactivated protein 1 (LGI1) antibodies are probably the most common cause of limbic encephalitis and the second most common cause of autoimmune encephalitis after anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (1).

The LGI1 gene provides instructions for making a protein called leucine-rich glioma inactivated 1 (Lgi1) or epitempin. This protein is found primarily in nerve cells (neurons) in the brain, including a part of the brain called the temporal lobe.

2025年3月30日 · LGI1 (Leucine Rich Glioma Inactivated 1) is a Protein Coding gene. Diseases associated with LGI1 include Epilepsy, Familial Temporal Lobe, 1 and Autosomal Dominant Epilepsy With Auditory Features. Among its related pathways are Nervous system development and LGI-ADAM interactions.

2024年1月7日 · Clinical features of nine cases of leucine-rich glioma inactivated 1 protein antibody-associated encephalitis. Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability.

LGI1, a secreted synaptic protein mutated to cause human partial epilepsy, regulates a seizure-induced circuit response by redistributing Kv4.2 channels to the neuronal surface in a transgenic mouse model.

Objective: To compare acute treatment responses and long-term outcome in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis. Methods: Retrospective case series of 118 patients with LGI1 antibody encephalitis evaluated at Mayo Clinic across all US sites from 1 …

2021年12月1日 · In this review, we will focus on LGI1 binding partners, “A Disintegrin And Metalloprotease (ADAM) 22 and 23”, the complex they form at the synapse, and will discuss the effects of LGI1 on neuronal excitability and synaptic transmission in …