2022年1月9日 · 淋巴球功能性抗原1（英文：Lymphocyte function-associated antigen 1, LFA-1）是淋巴球上的细胞黏附分子，属于黏附分子中整合素（integrin）超家族。 [1] LFA-1对淋巴球的迁移很重要，能帮助淋巴球离开血流并进入组织。LFA-1亦能帮忙减缓中性球的流速好让表皮细胞 …

Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. [1] LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues.

t细胞表面表达lfa-1，一种由两条肽链构成的黏附蛋白。 LFA-1的作用底物为ICAM-1（细胞黏附蛋白-1，也叫CD54），这是一种在血管内皮细胞和多种免疫细胞表面表达的蛋白。

属白细胞黏附受体成员，主要表达于淋巴细胞和髓样细胞，配体为icam-1～3，两者结合参与白细胞和淋巴细胞与血管内皮黏附，对白细胞向炎症局部移行以及淋巴细胞归巢和再循环起重要作用。

LFA-1局限在白细胞上表达,分布广泛,可参与细胞毒T细胞(cytotoxic T lymphocyte,CTL),自然杀伤细胞(natural kill cell,NK细胞)和淋巴细胞激活的杀伤细胞(lymphokine activated kill cell, LAK细胞)的杀伤效应;辅助性T淋巴细胞对外来抗原和丝裂原的增生反应;粒细胞及单核细胞介导的抗体 ...

LFA-1 (Lymphocyte function-associated antigen-1) is a heterodimeric integrin (CD11a/CD18) present on the surface of all leukocytes; it is essential for leukocyte recruitment to the site of tissue inflammation, but also for other immunological processes such as T cell activation and formation of the immunological synapse.

2021年8月1日 · LFA-1 is a mechanosensitive adhesion receptor that couples mechanical forces to fine-tune T cell migration, differentiation, and effector functions.

2019年4月9日 · The integrins LFA-1(CD11a/CD18) and Mac-1(CD11b/CD18) play overlapping roles in neutrophil migration because they bind the same as well as different ligands in response to extracellular...

2003年11月1日 · Nature Immunology - The LFA-1 integrin is known to mediate adhesion between T cells and antigen-presenting cells. New evidence, however, is provided for its role in transmitting signals that...

2018年5月3日 · Among several leukocyte-specific integrins, lymphocyte function-associated antigen-1 (LFA-1 or α L β 2; CD11a/CD18) is a key T cell integrin, which plays a major role in regulating T cell activation and migration. Adhesion to LFA-1's ligand, intracellular adhesion receptor 1 (ICAM-1) facilitates firm endothelium adhesion, prolonged contact ...