2025年3月30日 · LDHA (Lactate Dehydrogenase A) is a Protein Coding gene. Diseases associated with LDHA include Fanconi-Bickel Syndrome and Glycogen Storage Disease Of Heart, Lethal Congenital. Among its related pathways are glycolysis (BioCyc) and Regulation of …

2023年5月1日 · Lactate dehydrogenase (LDH) is an important enzyme of the anaerobic metabolic pathway. It belongs to the class of oxidoreductases, with an enzyme commission number EC 1.1.1.27. The function of the enzyme is to catalyze the reversible conversion of lactate to pyruvate with the reduction of NAD+ to NADH and vice versa.[1]

Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD +. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumors, and belongs to …

Gene ID: 3939, updated on 9-Feb-2025. This gene encodes the A subunit of lactate dehydrogenase enzyme which catalyzes the reversible conversion of pyruvate to lactate with the concomitant oxidation of NADH to NAD in anaerobic glycolysis. The protein is found predominantly in skeletal muscle and belongs to the lactate dehydrogenase family.

2025年2月9日 · This gene encodes the A subunit of lactate dehydrogenase enzyme which catalyzes the reversible conversion of pyruvate to lactate with the concomitant oxidation of NADH to NAD in anaerobic glycolysis. The protein is found predominantly in skeletal muscle and belongs to the lactate dehydrogenase family.

2023年3月24日 · Isoenzyme divergence is a prevalent mechanism governing tissue-specific and developmental stage-specific metabolism in mammals. The lactate dehydrogenase (LDH) isoenzyme spectrum reflects the tissue-specific metabolic status. We found that three tetrameric isoenzymes composed of LDHA and LDHB (LDH-3/4/5) comprise the LDH spectrum in T cells.

乳酸脱氢酶（lactate dehydrogenase，LD或LDH，EC1.1.1.27）是一类NAD依赖性激酶，有LDHA、LDHB、LDHC三种亚基，可构成6种四聚体同工酶。 动物乳酸脱氢酶是由4个亚单位组成的四聚体，常见的A、B两种亚基构成的5种LDH同工酶（LDH1-5），C亚基则仅组成一种LDH同工酶 …

There are four LDH genes: LDHA, LDHB, LDHC and LDHD (Figure 2). LDHA, LDHB and LDHC are L isomers, whereas LDHD is a D isomer. The L isomers use or produce L‐lactate, which is the major enantiomer found in vertebrates. Figure 1. The reaction catalyzed by lactate dehydrogenase (LDH).

2012年2月1日 · The LDHA gene provides instructions for making a protein called lactate dehydrogenase-A, which is one piece (subunit) of the lactate dehydrogenase enzyme. Learn about this gene and related health conditions.

2016年12月16日 · The LDHA gene encodes the A subunit of lactate dehydrogenase (EC 1.1.1.27), an enzyme that catalyzes the interconversion of lactate and pyruvate. The A subunit is expressed in skeletal muscle. Other isoforms include LDHB (150100), expressed in cardiac muscle, and LDHC (150150), expressed in testis (Tsujibo et al., 1985; Chung et al., 1985).