Feb 1, 2025 · LC3B drives autophagy via interaction with autophagy-related proteins, autophagosome-lysosome fusion, and transcriptional cofactor activity. LC3B modulates apoptosis, acting as a context-dependent regulator. Elevated LC3B levels in solid tumors highlight its potential as a cancer biomarker.

Mar 17, 2022 · In this study, we demonstrate that LC3B, a central protein in autophagy, is an RBP with a binding preference for the AAUAAA consensus motif. Direct binding of LC3B to mRNAs elicits rapid...

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Our recent study revealed that LC3B binds to RNAs with a preference for the consensus AAUAAA motif and recruits the CCR4-NOT deadenylase complex. Consequently, LC3B elicits rapid degradation of mRNAs, which we have termed as LC3B-mediated mRNA decay (LMD).

Microtubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family. It plays a crucial role in cellular autophagy and is involved in several vital biological processes, including apoptosis and …

LC3B is a marker of autophagic activity, and growing evidence supports its importance in myocardial hypertrophy. Thus, regulating LC3B expression may provide an important avenue to inhibit autophagy and protect against or inhibit pathological myocardial hypertrophy.

Microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein with a molecular mass of approximately 17 kDa that is distributed ubiquitously in mammalian tissues and cultured cells. During autophagy, autophagosomes engulf cytoplasmic components, including cytosolic proteins and organelles.

Mar 30, 2025 · MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include Pancreatic Ductal Adenocarcinoma and Smith-Mccort Dysplasia 2. Among its related pathways are Early SARS-CoV-2 Infection Events and Selective autophagy.

Feb 16, 2025 · The co-expression of LC3B and ESRRA might be a prognostic and therapeutic target for patients with bladder cancer. High levels of LC3B is associated with non-small cell lung cancer. LC3b was significantly overexpressed in malignant compared to benign prostate tissue.

To enable autophagy studies, we offer specific tools to report LC3B and p62 localization. Labeling of p62 serves as a useful marker for the induction of autophagy, clearance of protein aggregates, and the inhibition of autophagy.