LC3 lipidation is essential for TFEB activation during the lysosomal ...
Here we show that transcription factor EB (TFEB)-a master transcriptional regulator of lysosomal biogenesis and autophagy-is activated during the lysosomal damage response, and its …
转录因子EB(TFEB)的全方位综述 - 健康界
2022年8月19日 · 转录因子EB (TFEB)是自噬/溶酶体-核信号通路的中枢调控因子，参与能量稳态、应激反应、代谢、自噬和溶酶体生物发生等信号通路，与溶酶体储存障碍、神经退行性疾病、 …
Lysosomal damage due to cholesterol accumulation triggers
Through cell-based drug screening, we identified two antidepressants, sertraline and indatraline, as potent inducers of the nuclear translocation of TFEB (transcription factor EB). Activation of …
Past, present, and future perspectives of transcription factor EB …
2022年6月23日 · Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors, is an established central regulator of...
自噬标志物—LC3检测要点 - 知乎 - 知乎专栏
在哺乳动物中，存在 4 种LC3异构体（LC3A、 LC3B 、 LC3B2和 LC3C），在不同的组织细胞中表达会有差异。 目前主要研究的是LC3A和LC3B，LC3C在许多细胞中表达量很低，研究的也 …
Autophagy-independent function of lipidated LC3 essential for …
In our recent study, we found that a master transcription factor regulating autophagy and lysosomal biogenesis, TFEB (transcription factor EB) is activated during lysosomal damage, …
LC3蛋白：细胞自噬中的关键执行者 - 知乎 - 知乎专栏
LC3蛋白（也称为 Microtubule-associated protein 1 light chain 3）是一种与细胞自噬相关的蛋白质，在细胞自噬的过程中发挥重要的作用。 通过检测LC3蛋白的表达水平和形态变化，可以研究 …
Enhancing lysosomal biogenesis and autophagic flux by …
2017年2月27日 · We found that 50 μM Cd-induced accumulation of LC3-II or GFP-LC3 puncta was not significantly enhanced in the presence of CQ (Fig. 2b,c and S3a). Taken together, …
LC3 lipidation is essential for TFEB activation during the lysosomal ...
2020年9月28日 · Here we show that transcription factor EB (TFEB)—a master transcriptional regulator of lysosomal biogenesis and autophagy—is activated during the lysosomal damage …
Transcription factor EB (TFEB)-mediated autophagy protects …
2019年2月15日 · Western blots showed that 60 mM and 80 mM EC significantly increased the expression of LC3-II (a classic autophagosome marker), while lower concentrations (5, 20, 40 …