CD14—细菌脂多糖的膜受体 - 知乎 - 知乎专栏
CD14是革兰阴性菌内毒素脂多糖 LPS 和LPS结合蛋白 (LBP)复合物的高亲和力受体。 CD14识别并结合LPS，引起细胞酪氨酸磷酸化、核因子NF-κB转位、触发细胞因子释放和氧自由基产 …
Lipopolysaccharide (LPS)-binding protein stimulates CD14 ... - PubMed
2018年6月29日 · LPS stimulation of CD14-expressing cells induced TLR4 internalization in the presence of serum, and an inhibitory anti-LBP mAb blocked its internalization. Addition of LBP …
LBP作为LPS载体蛋白介导LPS的生物学效应 - 知乎 - 知乎专栏
一方面LBP-LPS复合物可以将LPS转递给膜型 CD14 （membrane CD14，mCD14）分子受体。 一定空间构象的LPS与单核细胞、巨噬细胞和中性粒细胞等细胞上的Toll样受体4（Toll-like …
Lipopolysaccharide (LPS)-binding protein stimulates CD14 …
Among the LBP/bactericidal/permeability–increasing protein family, LBP is unique in that it binds LPS micelle and transfers a monomer to CD14, which enhances the TLR4/MD-2 response …
An examination of the LPS-TLR4 immune response through the …
2025年3月18日 · CD14 plays a pivotal role in the LPS-TLR4 signaling pathway by recognizing LBP-delivered LPS and presenting it to TLR4, making LPS the first and most extensively …
揭秘脂多糖致病机制：LBP与CD14的调控网络 - 网易
2024年7月4日 · cd14，作为lps的特异性受体，其存在形式多种多样，主要包括膜联脂多糖受体（mcd14）和可溶性脂多糖受体（scd14）。mcd14作为一种膜蛋白，主要表达在成熟髓源性 …
Human Lipopolysaccharide-binding Protein (LBP) and CD14 …
In this study, we examined the role of LBP and CD14 in the physical generation of the ternary TLR1·TLR2·lipopeptide complex by performing biophysical measurements with functional …
Modulatory effects of sCD14 and LBP on LPS-host cell interactions
LPS binding protein (LBP) and CD14 play key roles in promoting innate immunity to Gram-negative bacteria by transferring LPS to the signaling receptor complex, MD-2/Toll-like …
Directed Evolution of an LBP/CD14 Inhibitory Peptide and Its Anti ...
2014年7月15日 · LPS-binding protein (LBP) and its ligand CD14 are located upstream of the signaling pathway for LPS-induced inflammation. Blocking LBP and CD14 binding might …
CD14: Biology and role in the pathogenesis of disease
2019年8月1日 · CD14 binds to Peptidoglycan (PGN) with partially identical conformational binding sites on CD14 compared with LPS and then leads to TLR2-mediated transcription factors NF …