艾伯特·霍夫曼第一次发现LSD时，将其记为 Lysergsäure-diäthylamid ，简写为LSD-25，指这是从麦角酸（ Lysergsäure ）衍生而来的第25种化合物。现代德语写作 Lysergsäurediethylamid 。因此LSD来自该德语单词。

Lysergic acid diethylamide (also known as Lysergide, LSD-25, LSD, L, Lucy, and Acid) is a classical psychedelic substance of the lysergamide class. It is perhaps the most researched and culturally influential psychedelic substance, as well as the prototypal lysergamide .

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Introduction.—The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dose level at which impairment becomes evident lies somewhere between 50μg. and 100μg.

Lysergic acid diethylamide (LSD-25 Sandoz) given orally in single doses as low as 20 micrograms produces depersonalization, derealization, and increased imagery in "normal" individuals. Larger doses are required to produce the same effect in psychotic patients.

The term LSD comes from the initials of the German for lysergic acid diethylamide, or Lysersäure Diethylamid. The number "25" following it has many myths attached to it, such as it was the 25th form of LSD that Hofmann tried, or it was his 25th attempt to make LSD.

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LSD is the best known and most researched psychedelic. It is the standard against which all other psychedelics are compared. It is active at extremely low doses and is most commonly available on blotter or in liquid form. Since 2013, some blotter and liquid "acid" being sold in the Americas and Europe contains NBOMe compounds instead of LSD.