The Jao Lab studies the principles of macromolecular assembly and the function of centrosomes, the micron-sized organelles that act as the microtubule-organizing center in animal cells. Current projects include understanding how the cell builds the centrosome and how the intracellular transport of centrosome-related proteins is regulated.

LE Jao, L Maddison, W Chen, SM Burgess. Briefings in Functional Genomics and Proteomics 7 (6), 427-443, 2008. 39: 2008: Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. LYM Liu, MH Lin, ZY Lai, JP Jiang, YC Huang, LE Jao, YJ Chuang.

TRACES: a Freely Accessible, Semi-automated Pipeline for Detection, Tracking, and Quantification of Fluorescently Labeled Cellular Structures. Bio Protoc. 2022 Aug 05; 12 (15). Jiang X, Jiang L, Jao LE. PMID: 36249859; PMCID: PMC9516249. Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly.

The Multicultural Mathematics Classroom: Culturally Aware Teaching through Cooperative Learning & Multiple Representations. Professional growth through reflection and an approximation of practice:...

2013年8月20日 · Here we report an improved CRISPR/Cas system in zebrafish with custom guide RNAs and a zebrafish codon-optimized Cas9 protein that efficiently targeted a reporter transgene Tg (-5.1mnx1:egfp) and four endogenous loci (tyr, golden, mitfa, and ddx19). Mutagenesis rates reached 75-99%, indicating that most cells contained biallelic mutations.

2022年2月12日 · Resolving force-function relationships in cells. Open Search. Search

Board of Trustees (2025–2026) April Hanson Board Chair Stay-at-home Mom, Austin, TX. Tom Lin, President InterVarsity Christian Fellowship/USA, Madison, WI. Claude Alexander

Yin L, Jao LE, Chen W Methods Mol Biol (2015) DOI: https://doi.org/10.1007/978-1-4939-2917-7_16 . Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

We study a tiny organelle named centrosome in the cell. The centrosome helps organize microtubules, the "skeletons" of the cell, so the cell can keep its shape and perform its function. A broken centrosome can cause many different human diseases.