2006年7月16日 · Here we show that leukaemia stem cells (LSC) can maintain the global identity of the progenitor from which they arose while activating a limited stem-cell- or self-renewal-associated programme.

2016年12月2日 · 早期的 LSCs 与先前确定的 LSCs (L-GMP) 不同，因为它们是 Sca-1 阳性的。 我们现在将 L-GMP 视为“晚期 LSC”类型之一。 早期的 LSC 在体外形成白血病菌落并在连续移植中引发 AML。

在骨髓分支中，CMPs 产生了 2 个更多的受限祖细胞，即巨核细胞-红细胞祖细胞 (MEPs) 和粒细胞-巨噬细胞祖细胞 (GMPs)，其中MEPs 产生了红细胞祖细胞和单能巨核细胞前体。 图 1A）。 8、9、28. 尽管经典的造血模型在其谱系潜力的二元概念中很简单，但这种造血模型已受到新祖种群鉴 …

2022年3月1日 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML). PDK1 low AMLs are OXPHOS-driven, are...

2016年7月11日 · GMP:MA9 bulk leukaemia cells and LSCs had significantly higher MA9 expression than CMP:MA9 bulk leukaemia cells and LSCs, respectively, consistent with the observation that higher levels of MA9...

2011年1月18日 · The more mature LSC population most closely mirrors normal granulocyte-macrophage progenitors (GMP) and the immature LSC population a previously uncharacterized progenitor functionally similar to lymphoid-primed multipotential progenitors (LMPPs).

2015年11月5日 · Using murine MLL-AF9 and MOZ-TIF2 AML models, we show that myeloid differentiation to granulocyte macrophage progenitors (GMPs) is critical for LSC generation. Disrupting GMP formation by deleting the lineage-restricted transcription factor C/EBPa blocked normal granulocyte formation and prevented initiation of AML.

2022年8月18日 · cd93+和l-gmp亚群与mll重排驱动的原代小鼠和人类患者amls的产生和维持直接相关。 值得注意的是，研究者们观察到，用STM2457处理后，CD93+和L-GMP群体显著减少，表明其对METTL3的催化功能有很强的依赖性(图4f)。

Here we show that AMP-activated protein kinase (AMPK), a metabolic checkpoint kinase, confers metabolic stress resistance to leukemia-initiating cells (LICs) and promotes leukemogenesis. Upon dietary restriction, MLL-AF9-induced murine AML activated AMPK and maintained leukemogenic potential.

GMP Synthetase (GMPS), an enzyme in de novo nucleotide biosynthesis, catalyzes the amination of xanthosine 5′-monophosphate (XMP) to guanosine 5′-monophosphate (GMP) in the presence of glutamine (the amine source) and ATP. [10, 12] GMPS possesses two active sites that are separated by approximately 30 Å, suggesting that GMPS undergoes a signific...