2023年9月27日 · The Kv2.1 voltage-activated potassium (Kv) channel is a prominent delayed-rectifier Kv channel in the mammalian central nervous system, where its mechanisms of activation and...

Potassium voltage-gated channel subfamily B member one, or simply known as KCNB1, is a delayed rectifier and voltage-gated potassium channel found throughout the body. The channel has a diverse number of functions. However, its main function, as a delayed rectifier, is to propagate current in its respective location.

2005年10月1日 · Kv2.1 is widely expressed in brain and composes the majority of delayed rectifier K + current in pyramidal neurons in cortex and hippocampus, and is also widely expressed in interneurons. Dynamic modulation of Kv2.1 localization and function by a mechanism involving activity-dependent Kv2.1 dephosphorylation dramatically impacts intrinsic ...

2020年7月1日 · Kv2.1 channels mediate cell death–enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl terminus (CT) of the cognate channel Kv2.2 is neuroprotective by disrupting Kv2.1 surface clusters.

2019年9月11日 · Kv2.1 voltage-gated potassium channels consist of two types of α-subunits: (a) electrically-active Kcnb1 α-subunits and (b) silent or modulatory α-subunits plus β-subunits that, similar to silent α-subunits, also regulate electrically-active subunits.

2025年1月6日 · Modulation of K + channels is widely used to dynamically regulate neuronal membrane excitability. The voltage-gated K + channel Kv2.1 is an abundant delayed rectifier K + (IK) channel expressed at high levels in many types of mammalian central neurons where it regulates diverse aspects of membrane excitability.

2005年10月1日 · Kv2.1 is widely expressed in brain and composes the majority of delayed rectifier K + current in pyramidal neurons in cortex and hippocampus, and is also widely expressed in interneurons. Dynamic modulation of Kv2.1 localization and function by a mechanism involving activity-dependent Kv2.1 dephosphorylation dramatically impacts intrinsic ...

Kv2.1是电压门控性钾离子通道(voltage-gated potassium channels, Kv)的成员之一，它构成了海马神经元中延迟整流钾电流的主要成分，因而可能对相关神经细胞的电活动和兴奋性具有重要作用。

2024年11月28日 · 研究人员首次揭示了Kv2.1钾离子通道是淀粉样蛋白A β 调控小胶质细胞炎症/神经元Tau过度磷酸化的桥梁，同时发现临床抗痉挛“老药”六氢芬宁 (Drofenine，Dfe) 作为Kv2.1抑制剂能够有效改善5×FAD模型鼠的阿尔兹海默症 (Alzheimer's disease, AD) 样病理症状。

Kv2.1 is a voltage-gated potassium (Kv) channel alpha-subunit expressed in mammalian heart and brain. MinK-related peptides (MiRPs), encoded by KCNE genes, are single-transmembrane domain ancillary subunits that form complexes with Kv …