《离子通道研究》——Kv1.3通道与自身免疫性疾病医药新闻-ByDru…
2024年7月17日 · Kv1.3表达受损会改变脂肪细胞和骨骼肌的胰岛素敏感性。大多数证据支持Kv1.3的表达与肿瘤行为和恶性肿瘤相关。Kv1.3存在于线粒体的内膜中，活性升高与细胞凋亡 …
KCNA3 - Wikipedia
Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or K v 1.3, is a protein that in humans is encoded by the KCNA3 gene. [5] [6] [7] Potassium …
Voltage-gated potassium channel 1.3: A promising molecular …
2024年6月1日 · Activation of Kv1.3 occurs when cell membrane voltage alters, allowing it to effectively target the cell surface and selectively permit potassium ion passage. Kv1.3 …
中国科大田长麟团队与南京大学董昊团队合作在自身免疫疾病重要靶标蛋白-电压门控K⁺通道Kv1.3 …
2021年6月1日 · Kv1.3是目前发现在T细胞中存在的主要钾离子通道之一，它的功能作用主要体现在对细胞膜电位的调节上。在抗原的呈递过程中，Kv1.3通道聚集在免疫细胞突触上并促进Ca2+ …
Structures of the T cell potassium channel Kv1.3 with …
2022年7月4日 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic...
Frontiers | Kv1.3 Channel as a Key Therapeutic Target for ...
2020年1月13日 · The voltage-gated potassium Kv1.3 channel is of interest, which is considered as a novel therapeutic target for treating neuroinflammatory disorders due to its crucial role in …
BioID-based intact cell interactome of the Kv1.3 potassium ... - AAAS
2024年9月4日 · Kv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear. We …
Potassium channels Kv1.3 and KCa3.1 cooperatively and ... - Nature
2017年3月1日 · Electrophysiology studies have implicated the potassium ion (K +) channel Kv1.3 as having a critical role in the regulation of chronically activated effector memory T (T EM) cell …
Structures of wild-type and H451N mutant human lymphocyte potassium ...
2021年6月1日 · K V 1.3 was the first ion channel discovered in immune cells three decades ago 2 and exhibited only C-type inactivation 3. During antigen presentation, the channel clusters at …
Adv Sci丨钾通道Kv1.3—OA 的潜在治疗靶点 - 知乎 - 知乎专栏
钾通道 Kv1.3 在调节许多炎症疾病中的免疫细胞功能方面发挥着重要作用，但其在骨关节炎(osteoarthritis，OA)中的研究还不是很多。 OA是最常见的退行性关节病，全球约有6.54亿人 …