Mouse mutants involving this gene have been used in studies of Zika virus pathogenesis. Note: these mice carry the same allele as 'G129' mice, although on a congenic C57BL/6, not 129, …

Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重 …

品系描述 通过敲除Ifngr1基因exon2，建立Ifngr1-KO (2)小鼠模型。 与此相似的品系还有Ifngr1-KO (NM-KO-18020)因技术原因已下架。 应用领域：免疫系统相关研究

There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.

The G129 (Ifngr1 KO) mice on a 129 background are a type II (γ) interferon receptor (Ifngr1) gene knockout model. The absence of the IFNGR1 protein in these mice results in defective gamma …

Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. The importance of IFNG in the immune systems in part from its ability to inhibit viral replication directly, and most …

Ifngr1/Ifnar1-KO This Ifngr1 and Ifnar1 double knockout strain is established by crossing Ifngr1-KO and Ifnar1-KO mice together.

Ifngr1-KO小鼠模型由赛业生物（Cyagen）采用基因编辑技术构建，旨在研究Ifngr1基因在小鼠体内的功能。 Ifngr1基因位于小鼠10号染色体上，由7个外显子组成，其中ATG起始密码子在1号外 …

2022年9月8日 · Here, we show that STING gain of function led to upregulation of IFN-γ–induced chemokines in the lungs of SAVI mice and that deletion of the type II IFN receptor (IFNGR1), …

2025年3月30日 · IFNGR1 (Interferon Gamma Receptor 1) is a Protein Coding gene. Diseases associated with IFNGR1 include Immunodeficiency 27A and Immunodeficiency 27B. Among …