Killer-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. [1][2] In humans, they are encoded in the leukocyte receptor complex (LRC) on chromosome 19q13.4; the KIR region is approximately 150 kilobases and contains ...

2025年3月30日 · KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) is a Protein Coding gene. Diseases associated with KIR3DL1 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and …

2024年2月28日 · 杀伤细胞免疫球蛋白样受体（Killer Cell Immunoglobulin-like Receptors, KIR，即CD158）是一个由14个多态性基因编码的受体家族（KIR2DL1 、 2DL2 、 2DL3 、 2DL4 、2DL5； KIR3DL1 、 3DL2 、 3DL3； KIR2DS1 、 2DS2 、 2DS3 、 2DS4 、 …

The establishment of a centralized, publicly accessible KIR database (IPD-KIR), collecting all the officially recognized nucleotide and protein sequences, has been of great help to all the immunologists involved in the study of KIR gene polymorphism (79).

2003年5月28日 · KIR genes are tandemly arrayed over about 150 kb, with the remarkable feature that gene content varies between haplotypes. The discovery of KIR has also imparted an additional function on the human leukocyte antigen (HLA) class I molecules, which are encoded by genes within the major histocompatibility complex (MHC; chromosome 6).

The IPD-KIR Database provides a centralised repository for human KIR sequences. Killer-cell Immunoglobulin-like Receptors (KIR) have been shown to be highly polymorphic at the allelic and haplotypic level.

To a high extent cytotoxic activity of NK cells is regulated inter alia by signals from killer immunoglobulin-like receptors (KIR). The major histocompatibility complex (MHC) class I molecules are important ligands for KIR receptors.

KIR genes are classified as belonging to one of three groups according to their structural features: 1) Type I KIR2D genes, which encode two extra-cellular domain proteins with a D1 and D2 conformation; 2) The structurally divergent Type II KIR2D genes which encode two extra-cellular domain proteins with a D0 and D2 conformation and finally; 3 ...

2022年1月20日 · Killer immunoglobulin-like receptors (KIR) regulate the function of natural killer cells through interactions with various ligands on the surface of cells, thereby determining whether natural killer (NK) cells are to be activated or inhibited from killing the cell being interrogated.

2017年6月1日 · The killer cell immunoglobulin-like receptor (KIR) region of human chromosome 19 contains up to 16 genes for natural killer (NK) cell receptors that recognize human leukocyte...