In biochemistry, a kinase (/ ˈ k aɪ n eɪ s, ˈ k ɪ n eɪ s,-eɪ z /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

Kinase, an enzyme that adds phosphate groups to other molecules. A large number of kinases exist, the human genome alone containing hundreds of kinase-encoding genes. Included among kinase targets for phosphorylation are proteins, lipids, and nucleic acids.

In this Special Issue “Protein Kinases: Function, Substrates, and Implication in Diseases”, we collected seven review papers and five original research articles, focused on new findings, recent advances and future development in the protein kinase field.

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

Protein and lipid kinases represent an important target class for treating human disorders. This review focus on ‘the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery.

2022年3月3日 · Regulation and Function of Protein Kinase. There are about 500 protein kinase encoding genes in the human genome which represents 2% of all the human genes. Kinase is the name given to an enzyme that adds a phosphate group (PO 4 3-) to other biomolecules such as protein, lipid, or nucleotides. This type of addition of a phosphate group is ...

2025年3月13日 · Beyond the catalytic core, regulatory domains influence kinase function. Some kinases possess autoinhibitory segments that block the active site until specific signals relieve inhibition. Others interact with scaffolding proteins that localize them to …

2023年12月1日 · What is a Kinase and How Does it Work in the Cell. Kinases are enzymes that help regulate cells of all living organisms by controlling signal transduction pathways. In essence, they act as a catalyst to “switch on/off” various cellular functions including metabolism and growth.

Susan Taylor gives an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily.

A kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. From: The World’s Health Care Crisis, 2011