2024年12月25日 · KRT8 (Keratin 8) is a Protein Coding gene. Diseases associated with KRT8 include Cryptogenic Cirrhosis and Cirrhosis, Familial. Among its related pathways are Keratinization and Nervous system development. Gene Ontology (GO) annotations related to this gene include structural molecule activity and scaffold protein binding.

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18. Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. [5] .

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial ...

Keratin 8 (K8) and keratin 18 (K18) are the most common and characteristic members of the large intermediate filament gene family expressed in ‘simple’ or single layer epithelial tissues of the body.

2021年8月26日 · Keratin 8 and keratin 18 (K8/K18) are intermediate filament proteins that form the obligate heteropolymers in hepatocytes and protect the liver against toxins. The mechanisms of protection include the regulation of signaling pathway associated with cell survival.

2025年2月9日 · Title: A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome. Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

2022年7月27日 · Keratin 8 (KRT8) is an important member of the keratin protein family and plays a role in regulating the cellular response to stress stimuli and mediating inflammatory reactions. However, the role of KRT8 in pancreatitis and PDAC is still poorly understood.

2016年9月2日 · Here we report that down-regulation of CK8 in mice enhanced TLR-mediated responses, rendering mice more susceptible to lipopolysaccharide (LPS)-induced endotoxin shock and Escherichia coli –caused...

Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. Results show K8 is present on the cell surface of transformed prostate cancer cell lines, and K8 increased the activity of plasmin approximately fivefold over a 48-h period.

Keratin 8 is one of the major intermediate filament proteins present in intestinal enterocytes of patients with IBD. So, mice deficient for Keratin 8 develop colonic hyperplasia and colitis due to a primary epithelial rather than immune cell defect.