Keratin 5, also known as KRT5, K5, or CK5, is a protein that is encoded in humans by the KRT5 gene. [5] [6] [7] It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells. [8] [9] This protein is involved in several diseases including epidermolysis bullosa simplex and breast ...

2024年12月25日 · KRT5 (Keratin 5) is a Protein Coding gene. Diseases associated with KRT5 include Epidermolysis Bullosa Simplex 2F, With Mottled Pigmentation and Epidermolysis Bullosa Simplex 2E, With Migratory Circinate Erythema. Among its related pathways are Cell junction organization and Developmental Cell Lineages.

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.

2025年2月9日 · Title: Keratin 5 in Lung Cancer Specimens: Comparison of Four Antibody Clones and KRT5 mRNA-ISH. KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes.

The complex network of keratin filaments in stratified epithelia is tightly regulated during squamous cell differentiation. Keratin 14 (K14) is expressed in mitotically active basal layer cells, along with its partner keratin 5 (K5), and their expression is down-regulated as cells differentiate.

2016年9月14日 · The KRT5 gene provides instructions for making a protein called keratin 5. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 5 is produced in cells called keratinocytes in the outer layer of the skin (the epidermis).

KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes. Clinicopathological features of cytokeratin 5-positive pulmonary adenocarcinoma. Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guerin instillation.

The KRT5 gene provides instructions for making a protein called keratin 5. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 5 is produced in cells called keratinocytes in the outer layer of the skin (the epidermis).

The KRT5 gene encodes keratin-5, which together with keratin-14 (KRT14; 148066) form the intermediate filament (IF) cytoskeleton in basal keratinocytes of stratified epithelia. Keratin-5 belongs to the type II (basic) gene family of IF proteins; in epithelia, distinct pairs of type I (acidic) and type II proteins are expressed to form an IF ...

用于研究简单型天疱疮Dowling-Meara型。 这个基因的人类同源物与Dowling-Degos病、简单型天疱疮和具有斑驳样色素沉着的天疱疮有关。 与人类KRT5 (角蛋白5)正交。 [由基因组资源联盟，2022年4月提供] Dir./Indir. Gene and alternative splicing annotation with AIR. 预测能激活骨架蛋白结合活性。 位于角蛋白丝和质膜上。 在包括消化系统、上皮、泌尿生殖系统、皮肤系统和感觉器官在内的几个结构中表达。 用于研究简单型天疱疮Dowling-Meara型。 这个基因的人类同 …