Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. [5] Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack and …

The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in …

2022年6月20日 · KEAP1 functions as (i) a substrate adaptor for a Cullin 3 (CUL3)-based E3 ubiquitin ligase that targets NRF2 for ubiquitination and proteasomal degradation, and (ii) a …

2025年3月30日 · KEAP1 contains reactive cysteine residues that act as sensors for endogenously produced and exogenously encountered small molecules, which react with sulfhydryl groups …

Keap1, encoded by the KEAP1 gene, was discovered in 1999. A two-hybrid screening assay identified it as a protein repressing Nrf2 transcriptional activity, sensitive to electrophiles [4]. It …

2025年3月4日 · Gene target information for KEAP1 - kelch like ECH associated protein 1 (human). Find diseases associated with this biological target and compounds tested against it …

2017年3月1日 · It is now widely accepted that Keap1 is the cysteine-based mammalian intracellular sensor for exogenous and endogenous electrophiles and oxidants, and that …

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox …

2023年3月31日 · KEAP1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of CULLIN 3 (CUL3)-based E3 ubiquitin ligase. KEAP1 regulates the activity of NRF2 and acts as a sensor …

2020年6月15日 · The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin …