Potassium voltage-gated channel subfamily A member 4 also known as Kv1.4 is a protein that in humans is encoded by the KCNA4 gene. [5][6][7] It contributes to the cardiac transient outward potassium current (I to1), the main contributing current …

2025年3月30日 · KCNA4 (Potassium Voltage-Gated Channel Subfamily A Member 4) is a Protein Coding gene. Diseases associated with KCNA4 include Microcephaly, Cataracts, Impaired Intellectual Development, And Dystonia With Abnormal Striatum and Episodic Ataxia, Type 2.

四种序列相关的钾通道基因——shaker、shaw、shab 和 shal——已在果蝇中被鉴定出来，并且每一种都被证明具有人类同系物。 该基因编码钾通道、电压门控、摇床相关亚家族的成员。 该成员包含六个跨膜结构域，在第四部分中具有振动型重复序列。 它属于 A 型钾电流类别，其成员可能在心脏动作电位快速复极化阶段的调节中起重要作用，因此可能影响心脏动作电位的持续时间。 [RefSeq 提供，2011 年 3 月] Potassium channels represent the most complex class of voltage …

Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily.

2025年2月8日 · Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4). [provided by Alliance of Genome Resources, Feb 2025]

2023年11月23日 · Title: Reduced excitability of gp130-deficient nociceptors is associated with increased voltage-gated potassium currents and Kcna4 channel upregulation. The experiments here demonstrate that Kv4.2, Kv4.3 and Kv1.4 all contribute to the generation of potassium channels in mature cortical pyramidal (CP) neurons; these channels play distinct roles ...

KCNA4的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为钾通道代表了最复杂类从功能和结构观点来看电压门控离子通道。

2021年5月18日 · Philipson et al. (1993) mapped a potassium channel gene, which they symbolized KCNA4, to 11q13.4-q14.1 by a combination of segregation in a panel of reduced human-mouse somatic cell hybrids and isotopic in situ hybridization.

Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in several cellular components, including asymmetric synapse; cell surface; and dendrite. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane.

2010年11月30日 · Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.