
KP小鼠_自发肿瘤模型小鼠_构建_价格-赛业生物
本模型携带LSL-Kras G12D和LSL-Trp53 R172H两种基因型。Kras G12D是人类肿瘤中常见的Kras基因的活化突变体,Trp53 R172H是p53基因的突变体。分别在这两个基因编码区和启动 …
032435 - KP, K;Fl/Fl Strain Details - The Jackson Laboratory
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KPC - 南模生物
KPC小鼠是目前成功建立的一种胰腺导管腺癌模型小鼠,具有很多与人胰腺癌相似的特点,如胰腺内皮细胞瘤形成,强烈的免疫反应。 80%的KPC小鼠出现了肝转移和肺转移的现象。 KPC小 …
A mouse model for the study of anti-tumor T cell responses in …
2021年9月27日 · The Kras-Lox-STOP-Lox-G12D p53 flox/flox (KP) mouse model faithfully recapitulates human LUAD but does not elicit tumor-specific T cell responses because …
热门推荐|自发性肿瘤小鼠——药物研发的好帮手 - 知乎
2022年11月11日 · 致力于加速肿瘤疾病药物研发,赛业生物在动物模型领域深耕多年,所搭建的药物筛选评价小鼠模型平台可为研究人员提供KPC、KP、 KC model 、 Apc-Min 等多类型的自 …
The KrasG12D;Trp53fl/fl murine model of undifferentiated ... - PLOS
2021年7月9日 · Here we describe our histologic, transcriptomic and immune characterization of inducible and transplanted KP UPS sarcomas in C57Bl/6 mice. Following intra-muscular lenti …
An immunogenic model of KRAS-mutant lung cancer enables …
Here we set out to develop mouse models of mutant KRAS-driven lung cancer with an elevated tumor mutational burden by expressing the human DNA cytosine deaminase, APOBEC3B, to …
SOD1 regulates ribosome biogenesis in KRAS mutant non-small ... - Nature
2021年4月15日 · Herein we describe the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model. Sod1 knockout markedly reduces tumor burden in vivo and …
CCL7 recruits cDC1 to promote antitumor immunity and facilitate ...
2020年11月30日 · Administration of CCL7 into lungs alone or in combination with anti-PD-1 significantly inhibits tumor development and prolongs the survival of KP and KL mice. These …
使用与生物安全级别 1 兼容的腺相关病毒载体在 KP 小鼠模型中生 …
结果 基于 Kras-Lox-STOP-Lox-G12D/p53 flox/flox (KP) 的肺腺癌小鼠模型通过气管内滴注基于腺病毒的或基于无肠、腺相关病毒的 Cre 递送系统来激活。 通过显微 CT 监测肿瘤随时间的生长。