Targeting the FGF19–FGFR4 pathway for cholestatic, metabolic, …
2024年1月11日 · This enteric BA–FXR to hepatic FGFR4–KLB crosstalk pathway mediated by FGF15 and FGF19 completes an essential endocrine circuitry critical for governing BA …
胆汁酸受体及其作用途径 - 知乎 - 知乎专栏
IR-1（inverted repeat-1），FXR 受体的结合反应元件。 ... 因子的重要受体之一，FGFR4特异性结合FGF19，而不结合FGF21或FGF23。并在FGFR4协同受体β-klotho (KLB)的辅助下，介导下 …
β-Klotho gene variation is associated with liver damage in children ...
2020年3月1日 · The KLB rs17618244 variant increases the risk of ballooning and lobular inflammation in children with NAFLD. ... (FXR) in enterocytes thus inducing the expression of …
Hepatic FXR-FGF4 is required for bile acid homeostasis via an …
2024年10月10日 · Song et al. identify hepatic FGF4 as a direct target of FXR in addition to ileal FGF15/19, which represses bile acid (BA) synthase genes Cyp7a1 and Cyp8b1. The effect of …
Frontiers | Biological and pharmacological functions of the FGF19
2023年5月15日 · Conversely, in the livers of FXR KO mice, Klb mRNA and protein levels were decreased . Therefore, FXR protects the liver against high BA levels by inducing Klb …
β-Klotho as novel therapeutic target in Metabolic Dysfunction ...
2024年11月1日 · In detail, chromatin immunoprecipitation analysis has revealed that FXR, a transcriptional regulator crucial in liver metabolism, exhibited binding sites at the Klb locus in …
Fibroblast Growth Factor 15/19 Expression, Regulation, and …
Bile acid signaling of FGF19-FGFR4 in the liver. fibroblast growth factor (FGF), fibroblast growth factor receptor (FGFR), β-Klotho (KLB), farnesoid x receptor (FXR), cytochrome P450 7A1 …
Metabolic Messengers: fibroblast growth factor 15/19 - Nature
2019年6月14日 · In fact, pharmacological FXR activation with the synthetic ligand GW4064 has been shown to transiently prime hepatic expression of the direct FXR target Klb; Fgfr4 and β …
Cell Metabolism | FXR激活可通过胆汁酸依赖方式降低脂质吸收从 …
肠道fxr介导脂质吸收变化，而肝脏fxr控制脂质合成 为确定NAFLD模型中肝脏脂质的FXR依赖性降低是否需要SHP，对WD饮食 Shp -/-小鼠进行GSK2324干预。 发现WD饮食的 Shp-/- 小鼠肝 …
靶向 FGF19-FGFR4 通路治疗胆汁淤积、代谢和癌性疾病,Journal of …
2024年1月11日 · 人成纤维细胞生长因子 19（fgf19 或啮齿动物中的 fgf15）通过负反馈机制在控制胆汁酸 （ba） 合成中起核心作用。这个过程涉及 ba 激活的回肠法尼醇 x 受体和肝 klotho β …