KCC2 is a potassium (K +)/chloride (Cl −) symporter that maintains chloride homeostasis in neurons. The electrochemical chloride gradient established by KCC2 activity is crucial for …

Sep 13, 2023 · Strategies focusing on direct (enhancing KCC2 activation) and indirect KCC2 modulation (altering KCC2 phosphorylation and transcription) have proven effective in …

KCC2 is a secondary active transporter, i.e., it uses the energy of the electrochemical K + gradient to transport Cl −. The electrochemical plasma membrane K + gradient is generated …

Oct 25, 2019 · 钾-氯共转运蛋白KCC利用这个钾离子浓度梯度，将细胞内的钾离子和氯离子一起转运至细胞外，从而调控细胞内的氯离子浓度。 氯离子浓度是一个很关键的指标。 例如，在γ- …

May 1, 2021 · KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule …

Our results show that KCC2 downregulation affects network activity primarily through enhanced neuronal excitability, suggesting novel targets for therapeutic intervention. We investigated the …

Nov 28, 2017 · KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, …

Nov 28, 2017 · KCC2 is a neuron specific K + -Cl - co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, …

The K +-Cl-co-transporter KCC2 is a neuron-specific, Cl-extruder that uses K + gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly …

The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl− extrusion pathway important in postsynaptic inhibition mediated by ligand-gated anion …