Chloride potassium symporter 5 - Wikipedia
KCC2 is a potassium (K +)/chloride (Cl −) symporter that maintains chloride homeostasis in neurons. The electrochemical chloride gradient established by KCC2 activity is crucial for …
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target …
2023年9月13日 · This review discusses the role of KCC2 in epilepsy and evaluates its potential as a drug target for epilepsy treatment by exploring various strategies to regulate KCC2 activity.
Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and ...
By regulating intraneuronal chloride homeostasis, KCC2 strongly influences the efficacy and polarity of the chloride-permeable γ-aminobutyric acid (GABA) type A and glycine receptor …
The Multifaceted Roles of KCC2 in Cortical Development - Cell Press
2021年2月24日 · KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional …
The Expanding Therapeutic Potential of Neuronal KCC2 - PMC
KCC2, encoded by SLC12A5, is a member of the solute carrier 12 (SLC12) family that is highly expressed in neurons [8,9]. Its function is vital for postnatal survival, as KCC2 knockout mice …
Structures and an activation mechanism of human potassium …
2020年12月11日 · In this study, we report full-length structures of human KCC2, KCC3, and KCC4, observe an autoinhibition by the N-terminal peptide, and reveal diverse dimeric …
KCC2, epileptiform synchronization, and epileptic disorders
Here, we will first summarize data regarding the role of KCC2 in epileptiform synchronization. Next, we will review evidence indicating that KCC2 expression and function are altered in …
Molecular architecture of potassium chloride co-transporter KCC2
2017年11月28日 · KCC2 is a neuron specific K + -Cl − co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain …
The Role of K+-Cl--Cotransporter-2 in Neuropathic Pain
In this review, the hypothesis that an alteration of KCC2 expression has a crucial influence on the initiation/development or maintenance of neuropathic pain is discussed. In addition, it is …
Molecular architecture of potassium chloride co-transporter KCC2
2017年11月28日 · KCC2 is a neuron specific K + -Cl - co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain …