mapk通路有4种主要的分支路线： erk 、 jnk 、 p38 /mapk和erk5。 其中，JNK和p38功能相似，跟炎症、凋亡、生长都有关；ERK主要管细胞生长、分化，其上游信号是著名的 Ras/Raf …

在真核细胞中已经确定了以下四条MAPK级联途径：ERK、 JNK 、 p38 MAPK 和ERK5信号转导途径。 今天我们来快速了解一下ERK/MAPK信号通路。 ERK是一种丝氨酸/苏氨酸蛋白激酶，是 …

2018年11月28日 · In this review, we summarize our current understanding of the roles of the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication in …

erk激酶是mek激酶的唯一下游靶点，研究显示，靶向于erk靶点的抑制剂能够有效阻断ras-raf-mek-erk信号通路，同时能够有效逆转由上游braf、mek突变而导致的耐药。

2002年3月1日 · MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. At least three MAPK …

2012年8月1日 · ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of substrates containing a Pro-Xxx-Ser/Thr-Pro sequence. Besides this …

In this review, we summarize our current understanding of the roles of the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication in controlling …

Persistent activation of the JNK or p38 signaling pathways has been suggested to mediate neuronal apoptosis in AD, PD, and ALS, whereas the ERK signaling pathway plays a key role …

2002年12月6日 · The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are …

2002年12月6日 · The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun …