2018年12月3日 · Mechanistically, TLR8, localizing in the endosomes and lysosomes, mediated ERK activation, inflammatory mediators' production, and neuronal hyperexcitability after SNL. …

2018年11月19日 · In this issue of JEM, Zhang et al. describe the role played by TLR8 in controlling neuropathic pain in mice. The work demonstrates that the microRNA miR-21 can …

we report that Tlr8−/− mice show normal itch behaviors, but have defects in neuropathic pain induced by spinal nerve ligation (SNL) in mice. SNL increased TLR8 expression in small …

2018年12月3日 · TLRs have been well characterized in the context of immunity, although TLR8 is understudied due to its controversial function in mice. In this issue of JEM, the new work by …

Here we report that Tlr8−/− mice show normal itch behaviors, but have defects in neuropathic pain induced by spinal nerve ligation (SNL) in mice. SNL increased TLR8 expression in small …

2013年12月16日 · We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed …

2018年11月19日 · The present study reveals a previously unknown role of TLR8 in the maintenance of neuropathic pain, suggesting that miR-21–TLR8 signaling may be potential …

It is proposed thatmiR21-mediated activation of TLR8 controls neuropathic pain and that activation ofTLR8 in response to MiR21 acts as a ‘spatially aggregating force’ to activate TLR7 …

In this issue of JEM, Zhang et al. describe the role played by TLR8 in controlling neuropathic pain in mice. The work demonstrates that the microRNA miR-21 can act as an endogenous ligand …

尽管tlr8在小鼠中的功能引起争议，但对tlrs的免疫功能已进行了很好的表征。 在本期JEM中，Zhang等人的新著作。 （https://doi.org/10.1084/jem.20180800）证明了由miR-21激活 …