JMJD3: a critical epigenetic regulator in stem cell fate
2021年7月3日 · The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an …
组蛋白去甲基化酶JMJD3研究进展 - 仁和软件
JMJD3 (Jumonji domain-containing protein 3)，又被称作KDM6B，是JMJD家族成员之一，JMJD3是含JmjC结构域的组蛋白去甲基化酶UTX/UTY家族成员之一，与UTX有84%的氨基 …
The role and prospect of JMJD3 in stem cells and cancer
2019年10月1日 · Jumonji domain-containing protein-3 (JMJD3), one of the demethyases of histone H3K27me3, has been reported to be associated with the prognosis of many cancers …
Inhibition of macrophage histone demethylase JMJD3 protects …
2021年6月7日 · Recent evidence suggests that an epigenetic enzyme, JMJD3, plays a critical role in establishing macrophage phenotype. Using single-cell RNA sequencing of human AAA …
JMJD3 in the regulation of human diseases | Protein & Cell
2019年11月7日 · The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune …
JMJD3 regulate H3K27me3 modification via interacting directly …
2024年2月29日 · H3K27me3, one of the common histone modifications, is involved in the regulation of stem cell maintenance and tumorigenesis by inhibiting gene transcription. we …
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to ... - Nature
2020年10月8日 · Here, we demonstrate that the histone H3 lysine 27 trimethylation (H3K27me3) demethylase JMJD3 plays conflicting roles in mouse reprogramming. On one side, JMJD3 …
JMJD3 is a histone H3K27 demethylase | Cell Research - Nature
2007年10月9日 · Through a candidate approach, we have biochemically identified JMJD3 as an H3K27 demethylase. Transfection of JMJD3 into HeLa cells caused a specific reduction of …
JMJD3 as an epigenetic regulator in development and disease
The Jumonji domain containing-3 (Jmjd3, KDM6B) and ubiquitously transcribed X-chromosome tetratricopeptide repeat protein (UTX, KDM6A) have been identified as H3K27 demethylases …
JMJD3: a critical epigenetic regulator in stem cell fate - PMC
The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic …