The JAK/STAT signaling pathway: from bench to clinic
2021年11月26日 · There are multiple pathways that promote the survival of CSCs in breast or colon cancer, which include IL-6-JAK1-STAT3, IL-6-JAK2-STAT3, hypoxia-inducible factor-1α-JAK1-STAT3, and retinol...
The role of IL-6/JAK2/STAT3 signaling pathway in cancers
2022年12月15日 · IL-6/JAK2/STAT3 signaling pathway plays a crucial role in the development and progression of cancer. JAK2/STAT3 can induce systemic inflammatory response and is associated with the occurrence of tumor cachexia (97, 98). IL-6 binds to membrane receptors and then activates non-receptor tyrosine kinases, including JAK2.
The JAK-STAT pathway: from structural biology to cytokine
2024年8月21日 · JAK2 signaling is crucial for maintaining hematopoietic stem cell (HSC) homeostasis, as hematopoietic cytokines like erythropoietin (EPO), thrombopoietin (TPO) and granulocyte-macrophage...
Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis
2022年2月25日 · This signaling pathway is tightly regulated and has a multitude of biological functions such as cell proliferation, differentiation, and apoptosis. Besides, the regulated JAK2/STAT3 signaling plays a crucial role in embryonic development, hemopoiesis, and controlling the immune system.
Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the ...
JAK/STAT3 activation by positive regulators is involved in drug- or radiation-resistance. CXCR4-mediated STAT3 activation induces gefitinib-resistance and transition into stem-like cancer cells, which possess self-renewal capacity and radiation resistance .
Targeting JAK2/STAT3 for the treatment of cancer: A review on …
2024年2月1日 · The downstream JAK2/STAT3 signaling cascades are legitimate targets against which newer anticancer drugs can be developed to prevent and treat cancer. Understanding the mechanisms behind JAK2/STAT3 participation in cancer has paved the way for developing innovative targeted medicines with the potential to improve cancer treatment outcomes.
The JAK-STAT pathway at 30: Much learned, much more to do
2022年10月13日 · The JAK/STAT pathway regulates multiple cellular processes across organisms. Molecular details of signaling mechanisms have revealed insights into a range of human diseases.
The JAK-STAT Pathway: Impact on Human Disease and …
Jak-mediated phosphorylation activates STATs, which in turn directly bind DNA and regulate gene expression (1, 2). There are four Jaks, Jak1, Jak2, Jak3, and Tyk2, which selectively bind different receptor chains (Figure 2).
comprehensive views of the JAK/STAT signaling pathway at the cellular, molecular, and genomic levels, and elucidate the relationship between JAK/STAT pathway components and human diseases.
Advances in the role of STAT3 in macrophage polarization
2023年4月3日 · According to one study, JAK2/STAT3 activity was significantly increased in rats with severe acute pancreatitis, and JAK2 inhibition increased levels of cytokines (such as Foxp3, IL-10, and TGF-β) necessary for M2 macrophage polarization, leading to a reduction in the secretion of pro-inflammatory factors IL-6, IFN-γ, and TNF-α, which ...
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