Irinotecan is a topoisomerase inhibitor [9] —it blocks the topoisomerase I enzyme, resulting in DNA damage and cell death. [8] Irinotecan was approved for medical use in the United States in 1996. [8] It is on the World Health Organization's List of Essential Medicines. [10]

2024年4月3日 · Irinotecan is used to treat cancers of the colon and rectum. It is usually given with other cancer medicines. Irinotecan may also be used for purposes not listed in this medication guide.

2025年3月1日 · Irinotecan can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are needed for proper blood clotting.

2023年7月21日 · Irinotecan is a medication used to manage and treat a variety of solid tumors. It is in the DNA topoisomerase I inhibitor class of drugs. Also known as CPT-11, irinotecan is used adjunctively with other therapeutic agents against colorectal cancer as a first- …

Irinotecan hydrochloride injection is a topoisomerase inhibitor indicated for: • First-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic carcinoma of the colon or rectum. ( 1)

Irinotecan hydrochloride is a type of chemotherapy drug called a topoisomerase I inhibitor. It causes breaks that cannot be repaired in the DNA of cells. This stops the growth of cancer cells and other rapidly dividing cells and causes them to die.

2024年4月2日 · Learn about the side effects of irinotecan, from common to rare, for consumers and healthcare professionals.

Irinotecan is a type of chemotherapy. It is a treatment for bowel cancer. Find out about how you have it, possible side effects and other important information.

Irinotecan is used to treat colon cancer and rectal cancer. It may sometimes be used to treat other cancers.

Find patient medical information for irinotecan intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.