Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. [4][5] Interferon regulatory factor 1 was the first member of the interferon regulatory transcription …

Mar 30, 2025 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related …

Jan 21, 2021 · Given the diverse array of effectors that exist in the IRF1 regulome, understanding the mechanisms underlying the protective role of IRF1 can be expected to provide key insights …

Innate immune signaling can induce the expression of interferon (IFN) regulatory factor 1 (IRF1), an important molecule in innate immune activation and cell death. While IRF1 has been shown …

irf1是最早发现的具备调节 干扰素 转录表达调控功能的高效调节因子。多年来并未完全揭示其在抗病毒天然免疫信号通路中的生物学功能。 多年来并未完全揭示其在抗病毒天然免疫信号通路 …

Jan 21, 2021 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I …

Sep 1, 2006 · Four IRFs — IRF1, IRF3, IRF5 and IRF7 — have been implicated as positive regulators of the transcription of type I IFN genes 4,14. IRF1 was the first IRF-family member …

编码的蛋白质激活参与机体对病毒和细菌反应的基因的转录，在细胞增殖、细胞凋亡、免疫反应和 DNA 损伤反应中发挥作用。 这种蛋白质抑制其他几个基因的转录。 作为肿瘤抑制因子，它既 …

Jul 8, 2019 · Here, we show that TNF regulates the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human FLSs as well as in a TNF transgenic arthritis …

我们发现巨噬细胞中的 TLR4 信号传导独特地与转录因子 IRF1 结合，从而促进 ISG 位点的转录开放。 这项研究为谱系特异性 TLR 反应提供了关键的机制基础，并揭示了 IRF1 作为人类巨噬 …