2024年12月25日 · IRAK3 (Interleukin 1 Receptor Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include Asthma-Related Traits 5 and Multisystem Inflammatory Syndrome In Children. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll Comparative Pathway.

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene. [5][6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells.

该基因编码白介素-1 受体相关激酶蛋白家族的成员。 该家族的成员是 Toll/IL-R 免疫信号转导通路的重要组成部分。 这种蛋白质主要在单核细胞和巨噬细胞中表达，并作为 Toll 样受体信号传导的负调节剂发挥作用。 该基因的突变与哮喘易感性有关。 交替剪接导致多个转录本变体。 [RefSeq 提供，2010 年 5 月] This gene encodes a member of the interleukin-1 …

2019年10月29日 · Interleukin-1 receptor associated kinase 3 (IRAK3) is a cytoplasmic homeostatic mediator of inflammatory responses and is potentially useful as a...

2021年3月4日 · In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.

2025年2月8日 · IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity. Findings demonstrated a distinctive role of IRAK-M in maintaining chronic Th2 airway inflammation and indicated a complex role for IRAK-M in the initiation and progression of experimental allergic asthma.

2014年10月7日 · Interleukin-1 receptor-associated kinase (IRAK) family members are mediators of TLR/IL1R superfamily signalling, and mounting evidence implicates these kinases as viable cancer targets.

2024年8月4日 · IL-1受体相关激酶-3 (IRAK3)是一种抑制IL-1/TLR信号的假激酶，癌症衍生因子可以通过增强IRAK3表达来抑制人类骨髓细胞的激活，但尚不清楚IRAK3如何促进人类髓细胞的免疫耐受，并调节患者对免疫疗法的反应。

IRAK3 is a critical modulator of inflammation in innate immunity. IRAK3 is associated with many inflammatory diseases, including sepsis, and is required in endotoxin tolerance to maintain homeostasis of inflammation.

2022年2月15日 · Interleukin-1 receptor associated kinase 3 (IRAK3) is a critical modulator of inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is known as a negative regulator of inflammation, several studies have reported opposing functions, and the temporal actions of IRAK3 on inflammation remain unclear.