2021年5月13日 · The fusion oncogene CBFβ-SMMHC expressed in AML with the chromosome inversion inv (16) (p13q22) acts as a driver oncogene in hematopoietic stem cells and induces AML.

1999年6月1日 · Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patients.

The inv(16)(p13q22)/t(16;16)(p13;q22) in acute myeloid leukemia results in multiple CBFB-MYH11 fusion transcripts, with type A being most frequent. The biologic and prognostic implications of different fusions are unclear.

In this review, we will discuss the current understanding of inv (16) preleukemia development, and the function of CBFβ–SMMHC related to preleukemia progression and LIC activity. We also discuss important open mechanistic questions in the etiology of inv (16) AML.

2025年3月14日 · The reciprocal translocations t(8;21), inv(16) or t(16;16), t(15;17), and translocations involving the 11q23 breakpoint are the most commonly identified chromosomal abnormalities.

This test is a highly sensitive quantitative assay for the detection of inv(16)(p13.1q22) or t(16;16)(p13.1;q22) CBFB::MYH11 gene fusion. This detection is useful for patients with acute myeloid leukemia at the time of diagnosis as well as for minimal residual disease monitoring during the clinical and therapeutic course of these patients.

Inv(16)(p13q22) is associated with acute myeloid leukemia subtype M4Eo, which is characterized by the presence of myelomonocytic blasts and atypical eosinophils. This chromosomal rearrangement results in the fusion of CBFB and MYH11 genes.

In a Blood Spotlight, Surapally et al highlight the current understanding of the molecular pathophysiology of the fusion oncogene CBFβ-SMMHC in driving inv (16) AML and discuss how that understanding informs potential novel therapies to improve disease prognosis.

2003年7月15日 · Acute myeloid leukemias (AMLs) carrying inv (16)/t (16;16) chromosomal abnormalities are associated with a good prognosis. However, studies of this AML subtype have been hampered by the few number of patients reported, frequently collectively considered with those with AML carrying the t (8;21) translocation.

2022年5月27日 · Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of secondary cytogenetic abnormalities.