SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans. [5] [6] [7] SHIP1 is expressed predominantly by hematopoietic cells [8] but also, for example, by …

2025年3月30日 · INPP5D (Inositol Polyphosphate-5-Phosphatase D) is a Protein Coding gene. Diseases associated with INPP5D include Hematologic Cancer and Crohn's Disease. Among …

2023年11月29日 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with …

2024年12月9日 · The gene inositol polyphosphate-5-phosphatase D (INPP5D), which encodes the lipid phosphatase SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is …

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Targeted PI3K/AKT-hyperactivation induces cell death in chronic …

2023年11月29日 · INPP5D is a gene specifically expressed in myeloid cells that encodes the protein src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 …

2023年4月15日 · Mutations in INPP5D, which encodes for the SH2-domain-containing inositol phosphatase SHIP-1, have recently been linked to an increased risk of developing late-onset …

2024年1月26日 · Inhibiting microglial AD gene INPP5D activates the inflammasome. In AD brain, INPP5D expression is up, but active protein is down. This triggers the inflammasome, …

2023年11月29日 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with …

2023年12月4日 · Clinical resource with information about INPP5D, A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci., Host-microbe …