2023年2月1日 · We focus on indoline compounds in development, synthesis and use as anticancer drugs, antibacterial drugs etc. in recent years. Through the analysis of the …

This is illustrated by the fact that the U.S. Food and Drug Administration (FDA) has recently approved several indole-based anticancer agents such as panobinostat, alectinib, sunitinib, …

2024年10月1日 · Rosuvastatin-based novel indole hybrids (46) were investigated by Shivakumar and his research group [66] as potential anti-cancer agents. Three of the synthesized …

A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were assessed for …

This review suggests a detailed explanation of multiple mechanisms of action of various indole derivatives: cell cycle arrest, aromatase inhibitor estrogen receptor regulator, tubulin inhibitor, …

2020年1月1日 · In light of the growing interest towards the preferential selection of indoline ring for the design of antiproliferative agents, this review attempts to present the recent …

2022年11月9日 · This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA …

2023年8月1日 · Extensive anticancer research has been conducted in this decade to evaluate their efficacy for diverse malignancies. The chapter explores the anticancer activity of natural …

2023年9月8日 · Indole-based various compounds show diverse medicinal properties including anticancer. This indole scaffold plays a vital role in the progression of anticancer drugs as a …

2023年3月13日 · This review analyzes the therapeutic benefit and clinical development of novel indole-based derivatives investigated as promising anti-GBM agents. The existing indole …