Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS. It is soluble white powder administered orally in combination with other antiviral drugs.

本品是一种蛋白酶抑制药，具有抗HIV-1和HIV-2蛋白酶作用，但对HIV-1的选择性高达10倍。 它与蛋白酶的活性部位可逆性结合，发挥竞争性抑制效应，从而阻止病毒前体多聚蛋白质的分裂并干扰新的病毒颗粒的成熟。 这种病毒颗粒仍处于未成熟状态中，故延迟了HIV细胞间的蔓延。 据此，蛋白酶抑制可阻止发生新的感染病灶。 体外研究证明，在细胞培养中，本品能抑制病毒播散。 这些细胞大多为从临床感染在分离到的HIV，包括耐齐多夫定和耐非核苷反转录酶抑制剂。 药物相 …

Indinavir is used along with other medications to treat human immunodeficiency virus (HIV) infection. Indinavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood.

2024年9月11日 · Indinavir is used alone or in combination with other anti-HIV medicines to treat infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Indinavir will …

Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a K i of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is …

Indinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1.

Indinavir is an antiretroviral protease inhibitor used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Indinavir can cause transient and usually asymptomatic elevations in serum aminotransferase levels and mild elevations in indirect bilirubin concentration ...

2020年2月25日 · What is indinavir used for? Indinavir is used to treat HIV infection. If you are allergic to indinavir; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

2023年10月30日 · Indinavir is a prescription medication used in combination with antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection.

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