2021年1月28日 · Several inflammatory factors including IL6, IL1β, S100A8, S100A9 and CXCL1 are downstream effectors of IL17A, meanwhile playing an important role in the pathogenesis of IMQ model, by determining their mRNA expression pattern, we found that IMQ modelling significant upregulated mRNA level of these factors in skin, while antibody (P = 0.032, 0. ...

2024年7月16日 · IMQ is an TLR7/8 agonist, which entry to the circulation after topical administration and leads to a systemic inflammation through the increased of inflammatory cytokines mRNA expression, especially TNF-α in the mice lungs and liver [55].

2009年5月1日 · Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce and exacerbate psoriasis, a chronic inflammatory skin disorder. Recently, a crucial role was proposed for the IL-23/IL-17 axis in psoriasis.

2024年7月16日 · The imiquimod (IMQ) cream was administered to the mice dorsal skin of the two groups to induce psoriatic inflammation. In the treatment group, IMQ was administered 10 min after hydrogel-containing M7 anti-IL-17A aptamer treatment.

咪喹莫特（imiquimod，IMQ）诱导的小鼠模型应用最为广泛，其不仅较好地模拟了银屑病样的皮损表现，也一定程度地存在与银屑病相似的固有免疫和获得性免疫紊乱。

The current study evaluated the therapeutic effects of M2 and M7 anti-IL17A ssDNA aptamers in the imiquimod (IMQ)-induced psoriasis mouse model. IMQ cream and Vaseline (Vas) were administered on the back skin of C57BL/6 mice as IMQ …

2023年12月1日 · In this study, we characterized spinal microglial activation in a mouse model of imiquimod (IMQ)-induced psoriasis. Hypertrophic (activated) microglia were observed throughout the spinal cord after the topical application of IMQ. Furthermore, the mRNA expression of microglial markers and inflammatory mediators was upregulated.

In this study, we characterized spinal microglial activation in a mouse model of imiquimod (IMQ)-induced psoriasis. Hypertrophic (activated) microglia were observed throughout the spinal cord after the topical application of IMQ. Furthermore, the mRNA expression of microglial markers and inflammatory mediators was upregulated.

An imiquimod (IMQ) induced wild type (WT) mouse can mimic some features of psoriasis, such as thickened skin, abnormal keratinocyte-related proteins, infiltration of inflammatory cells and pro-inflammatory cytokines. This model is a prevalent model ...

2023年5月25日 · The mRNA expression of Col1a1 and Col6a3 decreased significantly in MvdF250S/+ -IMQ mice compared to the WT-IMQ group, confirming a potential correlation between collagen production and the inflammatory reaction induced by IMQ.