ILK is also involved in regulating Erk, since overexpression of ILK prevents Erk inactivation during myogenic differentiation. ILK can also directly phosphorylate MLC in a calcium-independent manner, thus potentially regulating smooth muscle contraction and possibly cell motility in nonmuscle cells.

2022年1月28日 · Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions, cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal transductor and a scaffold protein through its interaction with integrins, then facilitating further protein recruitment within the ILK–PINCH–Parvin complex.

2014年4月1日 · Integrin-linked kinase (ILK) is a cytoplasmic protein that is commonly localised to focal adhesions. It comprises five ankyrin repeat domains at the N-terminus, a kinase domain at the C-terminus and a central a pleckstrin homology domain.

Proteomic analysis following Twist-mediated induction of EMT in MEC results in activation of FAK/ILK, mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), PI3K/Akt, and Wnt signaling, while depletion of ILK curtails Twist-mediated EMT and invasion , and depletion of Twist in breast cancer cells decreases activation ...

Ingenuity Pathways Analysis showed that integrin β1 (ITGB1) acts as a core regulator in linking integrin-linked kinase (ILK), Focal-adhesion kinase (FAK), MAPK/ERK, PI3K/AKT, and WNT signaling. Increased Twist and ITGB1 are associated with breast tumor progression.

该基因编码一种具有激酶样结构域和四个锚蛋白样重复序列的蛋白质。 编码的蛋白质在细胞膜上与 β 整合素的细胞质结构域结合，在此处调节整合素介导的信号转导。 这种蛋白质的活性在上皮到间充质的转化中很重要，并且这种基因的过度表达与肿瘤生长和转移有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 6 月] This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats.

2006年7月3日 · Here, we report that endogenous integrin-linked kinase (ILK) is a novel molecule that responds to hypoxia in ECs that regulates the expression of stromal cell–derived factor-1 (SDF-1) and intercellular adhesion molecule-1 (ICAM-1) through nuclear factor-κB and hypoxia-inducible factor-1α and induces recruitment of EPCs to ischemic areas.

2016年2月1日 · Ingenuity Pathways Analysis showed that integrin β1 (ITGB1) acts as a core regulator in linking integrin-linked kinase (ILK), Focal-adhesion kinase (FAK), MAPK/ERK, PI3K/AKT, and WNT signaling. Increased Twist and ITGB1 are associated with breast tumor progression. Twist transcriptionally regulates ITGB1 expression.

Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions, cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal transductor and a scaffold protein through its interaction with integrins, then facilitating further protein recruitment within the ILK–PINCH–Parvin complex.

2022年2月1日 · Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions, cell adhesion, and anchorage-dependent cell growth. It combines...