In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naïve CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, …

白细胞介素 4（IL-4）是主要由活化的 T 淋巴细胞、肥大细胞、嗜碱性粒细胞产生的一种多效性细胞因子。 1982 年 Howard 发现 T 细胞培养上清中有一种促进 B 细胞增殖的因子，起初命名为 …

Indeed, at the population level, CD4+ T-helper type 2 (Th2) cells express both IL-4 and IL-13. Even at the single cell level, co-expression of IL-4 and IL-13 (or IL-5 which largely tracks with …

自然杀伤细胞（NK细胞）分泌的 IFN-γ 不仅能促进巨噬细胞分泌IL-12，还能抑制Th2细胞的增殖，最终导致向Th1细胞分化。 Th2细胞的分化依赖于IL-4，IL-4是Th2引物和成熟所必需的。 它 …

2004年2月15日 · IL-4 is a potent inducer that directs differentiation of naive CD4 (+) T cells into CD4 (+) Th2 effector cells. To determine whether IL-4 can induce differentiation and …

Our findings establish that IL-4-induced epigenetic reprogramming is responsible for the development of inflammatory hyperresponsiveness to TLR activation and contributes to lung …

2003年7月1日 · Interleukin-4 (IL-4) is crucial for the differentiation of naive T helper (T H) cells into the T H 2 effector cells that promote humoral (antibody) immunity and provide...

2004年2月15日 · IL-4 is a potent inducer that directs differentiation of naive CD4 + T cells into CD4 + Th2 effector cells. To determine whether IL-4 can induce differentiation and expansion …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

2002年5月1日 · Although Gata3 is critical for Th2 polarization, it is not sufficient to mediate IL-4-driven cell expansion. We report that growth factor independent-1 (Gfi-1), a Stat6-dependent …