IL-4 regulates skin homeostasis and the predisposition towards …
IL-4-deficiency protects Stat6VT transgenic mice from the development of allergic skin inflammation and decreased recovery time in barrier function following skin irritation, with a …
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
The IL-4, IL-13 and IL-31 inflammatory pathways have been identified as hallmark features in the pathogenesis of the disease, contributing uniquely and synergistically to immune and barrier …
IL-4 impairs wound healing potential in the skin by repressing ...
Keratinocyte gene expression is critically shaped by IL-4, altering cell fate decisions likely important for the clinical manifestations and pathology of allergic skin disease. Keywords: …
Healing action of Interleukin-4 (IL-4) in acute and chronic ...
2025年1月1日 · Studies have shown that during skin repair, IL-4 activates macrophages to secrete resistin-like alpha (RELMα) and up-regulate lysyl hydroxylase 2, thereby regulating …
Trehalose Prevents IL-4/IL-13–Induced Skin Barrier Impairment by ...
2024年10月9日 · To investigate the effect of trehalose on skin barrier function, we treated monolayer-cultured postconfluent normal human KCs and LSEs with IL-4/IL-13 and/or …
IL-4Rα signalling in B cells and T cells play differential roles in ...
2023年1月4日 · Targeting interleukin 4 receptor alpha (IL-4Rα), an IL-4/IL-13 signalling axis, with dupilumab shows efficacy in AD. We investigated the importance of IL-4Rα signalling …
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL ...
2020年7月29日 · Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier …
Common and different roles of IL-4 and IL-13 in skin allergy and ...
Purpose of review: This review summarizes the mode of action of IL-4 and IL-13 in skin allergy, upcoming therapeutics and depicts key outcomes of the latest clinical trials. Recent findings: …
IL-4 acts on skin-derived dendritic cells to promote the TH2 …
2024年12月1日 · IL-4 acts on skin DCs that capture antigen and migrate to dLNs to promote their capacity for T H 2 polarization and drive allergic skin inflammation. Atopic dermatitis (AD) is …
The IL-4/IL-13 Axis in Skin Fibrosis and Scarring: Mechanistic …
IL-4 and IL-13 are important mediators of skin fibrosis, supported by evidence from in vitro data, animal models of fibrosis, and clinical studies. Overactive signaling of the IL-4/IL-13 axis …