The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with …

2024年3月29日 · 白细胞介素-4受体（IL-4R，又叫CD124；IL4Rα）是一种I型跨膜蛋白，属于白细胞介素家族成员之一。 IL4Rα链cDNA全长3.6 kb，含有一个编码825个氨基酸的开放阅读框 …

IL4R信号通路在免疫系统中具有重要作用，介导过敏性和Ⅱ型炎症反应。 IL4R在各种肿瘤中表达上调，通过迁移、浸润、存活、增殖等促进肿瘤转移。 目前FDA已批准几种靶向IL4R信号通 …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

2020年3月6日 · However, there is accumulating evidence showing that IL-4- and IL-13-mediated IL-4 receptor (IL-4R) signaling in both mouse and human neutrophils inhibits their migration …

白细胞介素-4 （IL-4） 是一种糖基化的I型细胞因子，具有三个链内二硫键，采用捆绑式四α螺旋结构。 主要由T细胞、自然杀伤T细胞、肥大细胞和嗜酸性粒细胞产生。 IL-4通过两种不同的受 …

2025年3月30日 · IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1. …

2016年12月1日 · Interleukin-4 is the prime anti-inflammatory cytokine involved in cell proliferation, gene expression and apoptosis. α chain of IL-4R is also a fundamental part of IL-13R hence, …

2025年2月8日 · The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane …

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex …