我和 IL4 是好兄弟——IL13 － 丁香通
2017年9月1日 · 白细胞介素-13（Interleukin-13）是白介素家族的重要成员，是由 IL-13 基因编码生成的蛋白质，分子量约 10KD。 IL-13 可由多种细胞分泌，如 CD4+T 细胞、CD8+T 细胞、 …
明星靶点IL4R：双重阻断IL-4和IL-13炎症信号通路 - 知乎
IL-13可以与气道上皮细胞表面Ⅱ型IL-4R中的IL-13Rα1亚基结合促使哮喘的发生，除此之外，还参与过敏和 特异性皮炎 等疾病进程。 IL-4对于肿瘤迁移和侵袭有很强的促进作用，同时IL-4在 …
Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα
Background: Dupilumab, a fully human monoclonal antibody that binds IL-4Rα and inhibits signaling of both IL-4 and IL-13, has shown efficacy across multiple diseases with underlying …
IL-4 and IL-13 induce equivalent expression of traditional M2
2023年11月10日 · IL-4 and IL-13 exhibited equivalent potency and efficacy for M2 marker induction, which was attenuated by STAT3 inhibition. Both cytokines enhanced PDBu …
COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING
IL-4 and IL-13 are short four α-helix bundle secreted glycoproteins with about 25% sequence similarity, encoded by adjacent genes that share several cis -acting transactivating regulatory …
白介素4（IL-4）和白介素13（IL-13） - 知乎专栏
IL-4 和 IL-13 是20世纪80年代早期发现的最早的细胞因子之一。 他们是结构和功能相关的细胞因子，都是短的四α-螺旋束分泌糖蛋白，其序列相似性约为25%，由共用几个反式激活调控区的相 …
IL-4/IL-13通路参与特应性疾病 - 知乎 - 知乎专栏
IL-4和IL-13是诱导和维持2型反应的关键细胞因子，并与多种特应性疾病有关，例如 特应性皮炎 （AD）、 哮喘 和 慢性鼻窦炎伴鼻息肉病 （CSwNP）。 几种选择性靶向2型通路增强因子的 …
Commentary: IL-4 and IL-13 receptors and signaling - PubMed
Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new …
Interleukin-4 and Interleukin-13 signaling | Pathway - PubChem
Interleukin-13 (IL13) is an immunoregulatory cytokine secreted predominantly by activated Th2 cells. It is a key mediator in the pathogenesis of allergic inflammation. IL13 shares many …
Structure, binding, and antagonists in the IL-4/IL-13 receptor system
2002年11月11日 · Interleukin-4 (IL-4) and IL-13 are the only cytokines known to bind to the receptor chain IL-4Rα. Receptor sharing by these two cytokines is the molecular basis for their …