Recent advances in understanding the role of IL-4 signaling
IL-4 induces elevated cell surface expression of CD23 (the low-affinity IgE receptor) on B cells and of class II major histocompatibility complex (MHC) molecules. In addition, IL-4 acts as a T-cell growth factor in both humans and mice and promotes the differentiation of Th2 cells.
Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα …
In the context of a T helper cell‐B cell interaction, IL‐4 produced by Th2 cells is thought to provide antigen‐specific help to B cells, promoting CD23 induction and isotype switching. 51 We show that only the dual ligand blocker (IL‐4Rα antibody) prevents B‐cell activation, as measured by increased cell surface of the low affinity ...
免疫调节达人之细胞因子— IL-4 - 知乎
IL-4 促进 B 细胞 MHCⅡ类抗原、FcεRⅡ/CD23 和 CD40 的表达，并增强 B 细胞提呈抗原能力，使免疫系统对小量抗原刺激发生免疫应答。 增加 FcεRⅡ/CD23 (IgE Fc 段低亲和力受体) 的表达，并释放可溶性 CD23 (sCD23)/IgE 结合因子 (IgE-BF)，与 mIgE 阳性细胞结合并诱导其分化，可能与促进B细胞 IgE 的产生有关。 IL-4 提高 LPS 刺激小鼠 B 细胞 IgG1、IgE 产生水平分别为 8～10 倍和 10～100 倍，但对 IgG3 分泌降低 6～10 倍，IgG2a、IgG2b 和 IgM 有不同程度下 …
IL-4 induced CD23 (Fc - ScienceDirect
2004年10月1日 · IL-4 has been shown to induce transient expression of CD23 on human PBMCs (Vercelli et al., 1988, Yokota et al., 1988), enhance the antigen-presenting ability of human bone marrow derived macrophages (Zlotnik et al., 1987), and human CD23 expression is increased in a number of allergic disorders both on B cells and monocytes (Pforte et al ...
Plasmablasts derive from CD23 - American Society of Hematology
2021年3月4日 · Activated B cells that differentiate into plasmablasts downregulate the CD23 marker and IL-4 pathway after an initial IL-4 response. CD23 – cells, which are preplasmablasts, also lose CBLB expression and increase IRF4 levels to promote plasmablast differentiation.
CD23-mediated cell signaling in human B cells differs from …
2010年12月1日 · In order to stimulate B cells through CD23 effectively, we up-regulated the surface expression of CD23 by treating B cells with IL-4 and SAC. Fig. 1 shows the percentage of non-treated (A) and treated B cells (B) positive for surface CD23.
Expression of CD23 antigen and its regulation by IL-4 in
The results indicate that IL-4 (i) increases CD23 expression and IgE-BFs production by normal and CLL B cells; (ii) does not promote B-CLLs proliferation or differentiation, neither by itself nor in costimulation with either anti-IgM or PMA; (iii) significantly potentiates PMA-induced IgM and IgE-BFs production by B-CLLs.
IL-4 Regulates Bim Expression and Promotes B Cell Maturation in …
2014年6月15日 · We found that IL-4 stimulated the generation of CD23 + transitional B cells from CD23 − B cells, and this effect was comparable to BAFF. IL-4 showed a unique protective effect against anti-IgM apoptotic signals on transitional B cell checkpoint, not observed with BAFF.
IL-4和IFN-γ对哮喘患儿淋巴细胞CD23表达的调控 - 百拇医药
2003年8月28日 · 本研究观察了白细胞介素4 (IL-4)和γ-干扰素 (IFN-γ)对哮喘和正常儿童淋巴细胞CD23表达的影响，以便进一步揭示CD23、IL-4、IFN-γ在哮喘发病机制中的作用。 1.1 研究对象 根据儿童哮喘诊断标准选择哮喘患儿24例，均处于发作期，男14例，女10例，年龄4～14岁，平均9岁。 正常儿童16例，男9例，女7例，年龄6～13岁，平均10岁。 1.2.1 细胞培养和刺激 将外周血淋巴细胞用RPMI 1640培养液配成1×10 6 ml -1 细胞浓度，留取1 ml 用于培养前CD23检测。
IGF-1 Potentiation of IL-4-induced CD23/FcεRII ... - ScienceDirect
2003年6月1日 · We report that in both human primary immune cells and established B cell lines, IGF-1 increased expression of the IL-4-induced type II IgE receptor (FcεRII/CD23). This effect was also seen at the mRNA level. IGF-1 increased the activity of signal transducer and activator of transcription 6 (STAT6) in response to IL-4, and activated NF-κB.