IL-35 suppresses T cell proliferation and converts naïve T cells into IL-35-producing iTr35. Here we show that IL-35 signals through a unique IL-12Rβ2:gp130 heterodimer or via homodimers.

IL-35 是 2002 年在第 13 届免疫学国际会议上被正式命名的一种新的抗炎 / 免疫抑制细胞因子 。 2007 年， Vignali 和 Liew 2 个小组分别发表了有关 IL-35 生物学功能的论文 ，使其成为近期免 …

IL35 is an immunosuppressive cytokine produced by Treg cells and plays an important role in many disease models. IL35 receptor (IL35R) consists of the IL12Rβ2 and gp130 domains. …

白细胞介素35 (IL-35)是由调节性而不是效应性T细胞产生的细胞因子，是IL-12家族中的一员，在免疫抑制中起作用。 它是一个由IL-12α链和IL-27β链组成的二聚体蛋白，分别由两个独立的基 …

Interleukin 35 (IL-35) is a recently discovered anti-inflammatory cytokine from the IL-12 family. Member of IL-12 family - IL-35 is produced by wide range of regulatory lymphocytes and plays …

[ 摘要] 白细胞介素35(interleukin-35,IL- 35) 是由EBI3 和p35 形成的IL- 12 家族新成员。 研究发现,IL- 35 不仅由调节性T(Treg)细胞分泌,还由其他多种免疫细胞分泌。 同时研究表明,IL- 35 在多 …

Interleukin-35 (IL-35), an inhibitory cytokine that belongs to the IL-12 family, is capable of potently suppressing T cell proliferation and inducing IL-35-producing induced regulatory T cells (iTr35) …

2012年2月5日 · IL-35 suppresses T cell proliferation and converts naive T cells into IL-35-producing induced regulatory T cells (iTr35 cells). Here we found that IL-35 signaled through a …

IL35 is a member of the IL12 family of cytokines, forms via heterodimerization of p35 and Ebi3, and is thought to signal in naïve CD4 + T cells through the IL35 receptor (IL35R, consisting of …

Interleukin-35 (IL-35), an inhibitory cytokine that belongs to the IL-12 family, is capable of potently suppressing T cell proliferation and inducing IL-35-producing induced regulatory T cells (iTr35) …