IL31RA Gene - GeneCards | IL31R Protein | IL31R Antibody
2025年3月30日 · IL31RA (Interleukin 31 Receptor A) is a Protein Coding gene. Diseases associated with IL31RA include Amyloidosis, Primary Localized Cutaneous, 2 and Primary …
【靶点新势力】炎症导向型IL-31，前路漫漫亦灿灿 - 知乎
Mitchga是全球首款通过竞争性抑制 IL-31RA 来抑制瘙痒的治疗性抗体，可有效改善特异性皮炎患者的生活质量。 细胞因子 是控制细胞通讯的关键。 白细胞介素31（IL-31）于2004年被发现 …
IL31RA - Wikipedia
Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene. [5] [6] [7] IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM …
Interleukin 31 receptor α promotes smooth muscle cell ... - Nature
2023年12月11日 · We show that IL-31RA functions as a positive regulator of muscarinic acetylcholine receptor 3 expression, augmenting calcium levels and myosin light chain …
Interleukin-31 Signaling Bridges the Gap Between Immune …
Recently, Interleukin (IL)-31 and its receptor complex attracted significant interest, as clinical phase two studies demonstrated therapeutic efficacy of the neutralizing IL-31 receptor A (IL …
炎症中的“瘙痒”细胞因子IL31
2024年10月17日 · Nemolizumab是第一个被批准上市的靶向IL31RA的单克隆抗体，它通过与IL31受体α相结合，可以阻断IL31的信号通路。 由Chugai Pharmaceutical开发用于治疗结节性 …
Interleukin-31: The "itchy" cytokine in inflammation and therapy
IL31RA expression is found on human and murine dorsal root ganglia neurons, epithelial cells including keratinocytes and various innate immune cells. IL-31 is a critical cytokine involved in …
The IL-31/IL-31 receptor axis: general features and role in ... - PubMed
IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed …
白介素 31 受体 A（IL31RA）基因 | MCE - MCE-生物活性分子 ...
该基因编码的蛋白质属于 I 型细胞因子受体家族。 这种与 gp130 同源的受体在单核细胞上表达，并通过激活 STAT-3 和 STAT-5 参与 IL-31 信号传导。 它既可以作为单体，也可以作为与制瘤素 …
IL-31：炎症和治疗中的“瘙痒”细胞因子 - 知乎
IL-31通过与IL-31受体α（IL-31RA）和抑瘤素M受体（OSMR）形成异源二聚体复合物进行信号传导，这些受体主要存在于上皮细胞和淋巴细胞上。 IL-31RA与OSMR的结合增强了IL-31的亲 …