
Interleukin 31 - Wikipedia
Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12. [5] [6] [7] IL-31 is an inflammatory cytokine that helps trigger cell-mediated …
【靶点新势力】炎症导向型IL-31,前路漫漫亦灿灿 - 知乎
2022年8月, 特应性皮炎 靶向药物 Nemolizumab (商品名Mitchga)于日本正式上市。 Mitchga是全球首款通过竞争性抑制 IL-31RA 来抑制瘙痒的治疗性抗体,可有效改善特异性皮炎患者的 …
白细胞介素-31(IL-31) - 丁香通研选
Sep 4, 2017 · il-31 受体主要分布于上皮细胞和淋巴细胞,il-31 通过与 il-31ra 和 osm r 组成的异源二聚体复合物结合激活 jak-stat、m apk、pi3k/ akt 信号通路传导信号。z. lei 等人通过 rt-pcr …
聚焦免疫 I 白介素IL31及受体IL31R - univ-bio.com
Nov 29, 2024 · 一、il31及il31ra IL31 binding数据检测,用ELISA方法,对IL31/OSMR,IL31/IL-31RA 进行结合检测实验。 图2:IL31/IL31RA,IL31/OSMR生物活性结合数据
The IL-31/IL-31 receptor axis: general features and role in ... - PubMed
IL31 protein, human IL31RA protein, human Interleukins Receptors, Interleukin STAT Transcription Factors Phosphatidylinositol 3-Kinases
Interleukin-31: The "itchy" cytokine in inflammation and therapy
The cytokine interleukin-31 has been implicated in the pathophysiology of multiple atopic disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper-reactivity. In AD, IL …
炎症中的“瘙痒”细胞因子IL31
Oct 17, 2024 · 白细胞介素31(il31)是一种促炎细胞因子,是il-6家族细胞因子的关键成员。il31与多种特应性疾病有关,例如特应性皮炎(ad)、过敏性鼻炎和气道高反应性。在ad中,il31已 …
IL-31:炎症和治疗中的“瘙痒”细胞因子 - 知乎
ATTO-1310是一款靶向IL31且具有延长半衰期的ATTOBODY,目前正在进行IND研究阶段,用于治疗特应性皮炎和其他瘙痒性疾病,预计将于2024年底启动临床试验;另一款靶向IL31xIL13的 …
小禾说 | 自身免疫疾病靶点与模型系列(21)——IL-31:瘙痒信使
ATTO-1310是一款靶向IL31且具有延长半衰期的ATTOBODY,目前正在进行IND研究阶段,用于治疗特应性皮炎和其他瘙痒性疾病,预计将于2024年底启动临床试验;另一款靶向IL31xIL13的 …
Interleukin-31 Signaling Bridges the Gap Between Immune …
IL-31 signaling bridges the gap between the immune system, neurons and epithelial surfaces. During T cell activation DOCK8 dissociates from EPAS1 enabling EPAS1 to translocate to the …