Mar 30, 2025 · IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include Immunodeficiency 63 With Lymphoproliferation And Autoimmunity and Ichthyosis. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic aneurysms. Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients.

Here we identify human interleukin-2 receptor (IL-2R) β chain (IL2RB) gene defects as a cause of life-threatening immune dysregulation. We report three homozygous mutations in the IL2RB gene of eight individuals from four consanguineous families that cause disease by distinct mechanisms.

In the current issue of JEM, Zhang et al. and Fernandez et al. describe a total of five kindreds with autosomal recessive mutations in IL2RB— seven affected live-born children with …

Sep 5, 2016 · Regulatory T cells (T reg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role...

IL2RB (–627C/C) homozygous genotype correlates with an increased predisposition to endometriosis. On the other hand, it is associated with lower susceptibility to gastric atrophy and low risk for cancer (outside cardia) during infection with Helicobacter pylori.

Jul 9, 2019 · The IL2RB gene encodes the beta subunit of the interleukin-2 (IL2) receptor, which transmits signals from the cytokines IL2 (147680) and IL15 (600554). IL2RB shows constitutive or induced expression on various types of immune cells, including CD4+ T regulatory cells, CD4+ and CD8+ T cells, B cells, and NK cells (summary by Zhang et al., 2019).

Aug 8, 2018 · With the cloning of IL-2 receptor α-chain (IL-2Rα, encoded by IL2RA; also known as CD25) 5, 6 and then IL-2Rβ (encoded by IL2RB; also known as CD122) 7, it became clear that IL-2Rα 5 lacks a ...

Apr 29, 2022 · The findings of the present premise illustrate that IL2RB plays an indispensible role in tumorigenesis, tumor metabolism, and immunity. Therefore, it is a prospective target gene in tumor-target therapy and tumor immune therapy. IL2RB is also a valuable predictive biomarker in most solid tumors.

IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms …