2016年8月22日 · In this study, using IL-21R.KO mice, we tested the role of IL-21/IL-21R signaling in the regulation of T helper cell responses during intestinal inflammation. Here we found that …

2016年8月22日 · Our results demonstrate that IL-21/IL-21R signaling contributes to protection against DSS-induced acute colitis through suppression of Th1 and activation of Th2, Th17 and …

2014年4月22日 · Studies using the dextran sodium sulphate (DSS) mouse model of colitis showed that treatment with DSS led to increased levels of IL-21 in gut tissue, and Il21 …

2023年6月27日 · Other studies have shown that IL-21/IL-21R(receptor) signaling may suppress intestinal inflammation in Dextran Sulphate Sodium (DSS)-induced colitis in mice through the …

2016年8月22日 · Our results demonstrate that IL-21/IL-21R signaling contributes to protection against DSS-induced acute colitis through suppression of Th1 and activation of Th2, Th17 and …

In vivo, after disease onset, DSS-induced intestinal inflammation was ameliorated in C57BL/6 mice treated with rIL-21. Our results demonstrate that IL-21/IL-21R signaling contributes to...

2013年5月1日 · Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21 …

2020年8月8日 · Anti-IL-21 administrated prevented DSS-simulative colitis via recovering claudin-5 expression in the human colonic epithelial cells. Meanwhile, we described that miR-423-5p …

In vivo, after disease onset, DSS-induced intestinal inflammation was ameliorated in C57BL/6 mice treated with rIL-21. Our results demonstrate that IL-21/IL-21R signaling contributes to …

2025年2月1日 · IL-21R KO mice were more susceptible to DSS-induced colitis than WT mice. The administration of recombinant IL-21 to WT mice improved the severity of DSS-induced colitis …