2018年7月18日 · Here we show that IL-15 induces autophagy in NKT cells with a mechanism that involves a crucial signaling component, TBK-binding protein 1 (Tbkbp1). Tbkbp1 facilitates activation of the...

2011年12月15日 · Global gene expression analyses and validation revealed that IL-15 regulated Tbx21 (T-bet) expression in thymic NKT cells. The loss of IL-15 also resulted in poor expression of key effector molecules such as IFN-γ, granzyme A and C, as well as several NK cell receptors, which are also regulated by T-bet in NKT cells.

IL-15 is a pleiotropic cytokine that regulates the development and maintenance of several subsets of innate lymphocytes, including γδ T, CD8αα T, NK and NKT cells (49). Furthermore, IL-15 signals the ontogeny, effector differentiation and Mcl-1-dependent survival of NK cells (50).

IL-15 is a cytokine critical for the development and homeostasis of natural killer T (NKT) cells, memory CD8 T cells, intraepithelial lymphocytes (IELs), and group 1 ILCs. 5,8,13,14 IL-15 forms a complex with the IL-15 receptor α (IL-15Rα), which is trans-presented to target cells and activates STAT5 and phosphatidylinositol 3-kinase (PI3K ...

IL-15 protected antigen-activated NKT cells from hypoxia, and transgenic expression of IL-15 in adoptively transferred NKT cells dramatically enhanced their antimetastatic activity in mice.

2021年2月1日 · Interleukin-15 (IL-15) has recently emerged as a novel immunomodulatory cytokine in cancer immunotherapy. IL-15 has the potential to reject and destroy cancer cells in the tumor microenvironment by expanding and activating natural killer (NK), natural killer T (NKT), and memory (m) CD8+T cells.

2011年5月1日 · In this study we show that IL-15-driven NKR induction in CD8+ T cells was linked with CD56 de novo acquisition, consistent with an effector-memory phenotype, increased anti-apoptotic levels, high granzyme B/perforin expression and with the ability of …

Vα24-invariant NKT cells inhibit tumor growth by targeting tumor-associated macrophages (TAMs). Tumor progression therefore requires that TAMs evade NKT cell activity through yet-unknown mechanisms. Here we report that a subset of cells in ...

2018年7月18日 · The cytokine IL-15 mediates development and survival of immune cells, including natural killer T (NKT) cells, but the underlying mechanism of IL-15 function is incompletely understood. Here we show that IL-15 induces autophagy in NKT cells with a mechanism that involves a crucial signaling component, TBK-binding protein 1 (Tbkbp1).

2019年12月1日 · Here, we evaluated whether coexpression of the NKT homeostatic cytokine IL15 with a CAR enhances the in vivo persistence and therapeutic efficacy of CAR-NKTs.